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Nuklearmedizin 1987; 26(04): 167-171
DOI: 10.1055/s-0038-1628883
Review Articles
Schattauer GmbH

Accuracy and Reproducibility of the Assessment of the Global Ejection Fraction Using 195mAu and a Single-Crystal Digital Gamma Camera: Influence of Collimator Design

Genauigkeit und Reproduzierbarkeit der Beurteilung der globalen Ejektionsfraktion mit 195m Au und einer Einkristall-Digital-Gamma-Kamera: Einfluss des Kollimator-Designs
G. Zatta
*   From the Nuclear Medicine Department, Milan, Italy
,
G. L. Tarolo
*   From the Nuclear Medicine Department, Milan, Italy
,
M. Gallazzi
*   From the Nuclear Medicine Department, Milan, Italy
,
A. De Agostini
*   From the Nuclear Medicine Department, Milan, Italy
,
A. Albertini
**   Istituto di Scienze Mediche Bassini, Milan, Italy
,
Maria Radice
**   Istituto di Scienze Mediche Bassini, Milan, Italy
,
D. Alberti
***   Milan University School of Medicine and the CIBA Foundation, Milan, Italy
› Author Affiliations
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Publication History

Received: 24 February 1987

Publication Date:
04 February 2018 (online)

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A sequence of RAO first-pass studies (first with 99mTc and then twice with 195mAu) was performed in 18 normal volunteers and in 12 CAD patients using two different types of collimator for medium energy: a standard collimator (MEMS) and a special high-sensitivity collimator (MEHS). The following data were compared: the peak count rate, the net LV end-diastolic counts and the LVEF. Using MEMS the end-diastolic counts acquired were so low (12% of 99mTc average value) that EF standard deviation had a mean value of 0.061 (range 0.045-0.081). With MEHS the following results were obtained: 1. the peak count rate and LV net end-diastolic counts with 195mAu were 55% and 50% respectively, of 99mTc values; 2. a good correlation was shown between LVEF values either with 99mTc and 195mAu (r =.97), or with 195mAu sequential studies (r =.98).

Zusammenfassung

Erste-Passage-Untersuchungen in RAO (zunächst mit 99mTc, dann zweimal mit 195mAu) wurden bei 18 Gesunden und bei 12 Patienten mit koronarer Herzkrankheit durchgeführt. Hierbei wurden zwei unterschiedliche Mittelenergie-Kollimatoren eingesetzt: ein Standard-Kollimator (MEMS) und ein spezieller hochempfindlicher Kollimator (MEHS). Folgende Daten wurden verglichen: die maximale Zählrate, die linksventrikuläre enddiastolische Zählrate (netto) und die linksventrikuläre Auswurffraktion. Mit MEMS waren die enddiastolischen Zählraten so niedrig (12% des Technetium-Wertes), daß die Streubreite der Auswurffraktion einen Mittelwert von 0,061 (Streubereich 0.045-0.081) aufwies. Für den MEHS betrugen maximale Zählrate bzw. linksventrikuläre enddiastolische Zählrate mit 195mAu 55% bzw. 50% der Technetium-Werte. Für die Werte der Auswurffraktion ergab sich eine gute Korrelation (99mTc vs 195mAu: r = 0.97). Die 195mAu-Werte waren exzellent reproduzierbar (r = 0.98).

 

  • REFERENCES

  • 1 Ackers J. G, DeJong R. B. J. Dosimetry consequences of eluates from 195mHg/195mAu generators. J. nucl. Med 1982; 23: P68.
    Search in Google Scholar
  • 2 Dymond D. S, Elliot A. T, Flatman W. et al. The clinical validation of Gold-195 m: A new short half-life radiopharmaceutical for rapid, sequential, first pass angiocardiography in patients. J. Amer. Coll. Cardiol 1983; 02: 85-92.
    CrossrefPubMedSearch in Google Scholar
  • 3 Dymond D. S, Caplin J. L, Flatman W. et al. Temporal evaluation of changes in left ventricular function induced by cold pressor stimulation. An assessment with radionuclide angiography and Gold-195 m. Brit. Heart J 1984; 51: 557-64.
    CrossrefPubMedSearch in Google Scholar
  • 4 Fazio F, Gerundini P, Maseri A. et al. Clinical assessment of left ventricular ejection fraction with short-lived 195mAu. J. nucl. Med 1982; 26: 105-11.
    Search in Google Scholar
  • 5 Fazio F, Gerundini P, Margonato A. et al. Quantitative radionuclide angiocardiography using Gold-195 m. Amer. J. Cardiol 1984; 53: 1442-6.
    CrossrefPubMedSearch in Google Scholar
  • 6 Harmutz B. Nuclear data sheet for 195mAu. Nuclear Data Sheets 1978; 23: 607-69.
    CrossrefSearch in Google Scholar
  • 7 Mena I, Narahara K. A, De Jong R. B. J, Maublant J. Gold-195 m, an ultra-short-lived generator-produced radionuclide: Clinical application in sequential first-pass ventriculography. J. nucl. Med 1983; 24: 139-44.
    PubMedSearch in Google Scholar
  • 8 Narahara K. A, Mena I, Maublant J, Brizedine M, Criley J. M. Simultaneous maximal exercise radionuclide angiography and thallium stress perfusion imaging. Amer. J. Cardiol 1984; 53: 812-7.
    CrossrefPubMedSearch in Google Scholar
  • 9 Wackers F. J, Giles R. W, Hoffer P. B. et al. Gold-195 m, a new generator-produced short-lived radionuclide for sequential assessment of ventricular performance by first pass radionuclide angiocardiography. Amer. J. Cardiol 1982; 50: 89-94.
    CrossrefPubMedSearch in Google Scholar
  • 10 Wackers F. J, Stein R, Pylik L. et al. Gold-195 m for serial first-pass radionuclide angiocardiography during up-right exercise in patients with coronary artery disease. J. Amer. Coll. Cardiol 1983; 02: 497-505.
    CrossrefPubMedSearch in Google Scholar