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Nuklearmedizin 1995; 34(04): 156-160
DOI: 10.1055/s-0038-1629818
Original Article
Schattauer GmbH

Optimal Sampling Times for OIH-Clearance Calculations Using a Two-Compartment/Two-Sample Method

P. Koranda
1   From the Dept. of Nuclear Medicine, Inselspital, University of Berne, Switzerland, and the Olomouc, Czech Republic
,
D. Lüscher
1   From the Dept. of Nuclear Medicine, Inselspital, University of Berne, Switzerland, and the Olomouc, Czech Republic
,
S. Lourens
1   From the Dept. of Nuclear Medicine, Inselspital, University of Berne, Switzerland, and the Olomouc, Czech Republic
,
H. Rösier
1   From the Dept. of Nuclear Medicine, Inselspital, University of Berne, Switzerland, and the Olomouc, Czech Republic
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 09. Mai 1994

in revised form: 24. Februar 1995

Publikationsdatum:
03. Februar 2018 (online)

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Summary

Orthoiodohippurate (OIH) clearance data obtained with the two-compartment/two-sample method of Lear which uses varying sampling time combinations, were compared with those of the reference two-compartment/multi-sample method of Sapirstein. A total of 35 studies were performed in 33 adult patients. The OIH clearance values determined by the reference method ranged from 107 to 883 ml/min/1.73 m2, with a median of 406 ml/min/1.73 m2. It was ascertained that the precision of the Lear method is partially dependent upon the sampling time combination. The most reliable results with the Lear method in this patient population were obtained by taking a first sample at approximately 8 min p. L, and a second sample at 32 min p. i. or later.

Zusammenfassung

Die mit Hilfe der Zweikomipartiment/Zweiproben-Methode nach Lear bei verschiedenen Blutentnahmezeiten bestimmten Jod-Hippuran-Clearancewerte wurden mit jenen der Zweikompartiment/Multiproben-Methode nach Sapirstein verglichen. Insgesamt wurden 35 Studien bei 33 erwachsenen Patienten ausgewertet. Die mit der Zweikompartiment/Multiproben-Methode bestimmten OIH-Clearancewerte lagen im Bereich von 107 bis 833 ml/min/1,73 m2, mit einem Median von 406 ml/min/1,73 m2. Es wurde festgestellt, daß die Genauigkeit der Lear-Methode von den Zeitpunkten der Blutentnahme abhängig ist. Die besten Ergebnisse brachte sie, wenn die erste Blutentnahme 8 min und die zweite 32 min p. i. (oder später) erfolgte.

Key words

Radionuclide studies - quantitative renal function - orthoiodohippurate clearance - effective renal plasma flow

Schlüsselwörter

Radionuklidstudien - quantitative Nierenfunktion - Jod-Hippuran-Clearance - effektiver renaler Plasmafluß
 

  • References

  • 1 Lear JL, Feyerabend A, Gregory Ch. Two-compartment, two-sample technique for accurate estimation of effective renal plasma flow: theoretical development and comparison with other methods. Radiology 1989; 172: 431-6.
    CrossrefPubMedGoogle Scholar
  • 2 Sapirstein LA, Vidt DG, Mandel MK, Hanu-sek G. Volumes of distribution and clearances of intravenously injected creatinine in the dog. Am J Physiol 1955; 181: 330-5.
    Google Scholar
  • 3 Tauxe WN, Dubovsky EV, Mantle JA, Dustan HP, Logic JR. Measurement of renal plasma flow in congestive heart failure. Eur J Nucl Med 1981; 6: 555-9.
    PubMedGoogle Scholar
  • 4 Tauxe WN, Dubovsky EV, Kidd T, Diaz F, Smith LR. New formulas for the calculation of effective renal plasma flow. Eur J Nucl Med 1982; 7: 51-4.
    PubMedGoogle Scholar
  • 5 Truniger B, Donath A, Kappeler M. Simplified clearance technique. The single injection method and its modifications. Helv Med Acta 1968; 34: 116-29.
    PubMedGoogle Scholar