Influence of Blood Viscosity on Circulatory Parameters Determined by First-Pass Radionuclide Angiocardiography in Cor pulmonale

Katalin Zámbó; K. Tóth

doi:10.1055/s-0038-1632292

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1993; 32(06): 288-291
DOI: 10.1055/s-0038-1632292

Originalarbeit

Schattauer GmbH

Influence of Blood Viscosity on Circulatory Parameters Determined by First-Pass Radionuclide Angiocardiography in Cor pulmonale

Einfluss der Blutviskosität auf die Kreislaufparameter bestimmt durch First-Pass-Radionuklid-Angiokardiographie in Cor pulmonale

Authors

Katalin Zámbó

¹From the Department of Nuclear Medicine
K. Tóth

²1st Department of Medicine, Division of Cardiology University Medical School of Pécs, Hungary

Abstract

Summary

First-pass radionuclide angiocardiography (FPRNA) with ^99mTc-albumin was performed in 19 patients with cor pulmonale. Pulmonary circulation time (PCT), mean transit time (MTT), pulmonary stagnation index (PSI) were calculated from the time-activity curves for the estimation of cardiopulmonary circulation. Whole blood viscosity (WBV), plasma viscosity (PV) and hematocrit (HTC) were also measured on the same day. Significant prolongation of all parameters was observed (WBW: 5,04 ± 1.19 mPas; PV: 1,36 ± 0,17 mPas; HTC: 47,6 ±2,37%; PCT: 7,10 ± 2,15 s; MTT: 9,33 ±4,11 s; PSI: 1,30 ±0,37) in patients with cor pulmonale. Significant positive correlations were found between PCT and WBV (r = 0,552; 0,001 <P <0.01), MTT and WBV (r = 0,34; P <0,05), furthermore between PCT and HTC (r = 0,356; P <0,05). The results suggest that hemorheological parameters may influence the results of FPRNA, therefore, they should be determined in addition to the radionuclide study.

Zusammenfassung

Die First-Pass Untersuchung (FPRNA) mit ^99mTc-Albumin wurde bei 19 Patienten mit Cor pulmonale durchgeführt. Pulmonale Zirkulationszeit (PCT), »mean transit« Zeit (MTT), pulmonaler Rest Index (PSI) wurden ermittelt aus den Zeit-Aktivitätskurven zur Einschätzung des kardiopulmonalen Durchflusses. Vollblut-Viskosität (WBV), Plasma-Viskosität (PV) und Hämatokrit (HTC) wurden am selben Tag gemessen. Bezeichnend für Patienten mit Cor pulmonale war eine typische Vergrößerung aller Parameter (WBV: 5,04 ± 1,19 mPAS; PV: 1,36 ± 0,17 mPAS; HTC: 47,6±2,37%; PCT: 7,10±2,15s; MTT: 9,33 ±4,11 s; PSI: 1,30 ±0,37). Verwertbare Korrelationen wurden zwischen PCT und WBV (r = 0,552; 0,001 <p <0,01), MTT und WBV (r = 0,34; p <0,05) sowie zwischen PCT und HTC (r = 0,356; p <0,05) gefunden. Die Resultate zeigen, daß hämorheologische Parameter einen Einfluß auf die Werte der FPRNA haben. Deswegen sollten diese Bestimmungen stets zusammen mit der FPRNA durchgeführt werden.

Key words

First-pass radionuclide angiocardiography - cardiopulmonary circulation - Cor pulmonale - blood rheology

Schlüsselwörter

First-pass Untersuchung - kardiopulmonaler Durchfluß - Cor pulmonale - BlutRheologie

Full Text

References

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