Nuklearmedizin 1998; 37(08): 297-298
DOI: 10.1055/s-0038-1632352
Originalarbeiten — Original Articles
Schattauer GmbH

Human Chorionic Gonadotropin and CA 15-3 Producing Adenocarcinoma

Human Chorionic Gonadotropin und das CA 15-3 produzierende Adenokarzinom der Lunge
G. Üçkaya
1   Department of Internal Disease, Gülhane Military Medical Academia, Ankara, Turkey
,
A. Özet
2   Department of Medical Oncology, Gülhane Military Medical Academia, Ankara, Turkey
,
A. Arpaci
2   Department of Medical Oncology, Gülhane Military Medical Academia, Ankara, Turkey
,
S. Kömiircü
2   Department of Medical Oncology, Gülhane Military Medical Academia, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

Received: 01 October 1997

in revised form: 06 August 1998

Publication Date:
03 February 2018 (online)

Summary

50 years old man suffering from primary lung adenocarcinoma presented with high levels of both beta subunit human chorionic gonadotropin (βHCG) and cancer antigen 15-3 (CA 15-3) in the absence of elevated carcinoembrionic antigen (CEA), alfa fetoprotein (AFP) and carbohydrate antigen 19-9 (CA 19-9). Although βHCG or CA 15-3 high levels were reported in adenocarcinoma of lung, this is the first report of a patient with high levels of both markers.

Zusammenfassung

Im Blut eines 50jährigen Mannes, der an einem primären Adenokarzinom der Lunge litt, wurden hohe Werte für die Spiegel der beiden Sub- unit-Formen von Human Chorionic Gonadotropin (βHCG) und Krebsantigen 15-3 gefunden, während die Spiegel von CEA, AFP und CA 19-9 normal waren. Obwohl hohe Anteile an βHCG und an Ca 15-3 vorher bekannt waren handelt es sich um den ersten Bericht mit hohen Blutspiegeln für beide Krebsmarker.

 
  • References

  • 1 DeVita Jr. VT, Hellman S, Rosenberg SA. Cancer principles and practice of oncology.. 5th ed. Philadelphia: Lippincott-Raven Publishers; 1997: 546-52.
  • 2 Jacobs EL, Haskell CM. Clinical use of tumor markers in oncology.. London: Blackwell Scientific Publications; 1992: 301-60.
  • 3 Klepp O, Romslo I. Tumor markers – an update: Proceeding from the first meeting on tumor markers. Trondheim. 1991: 8-105.
  • 4 Daar AS, Lennox ES. Tumor markers.. London: Blackwell Scientific Publications; 1987: 1-23.
  • 5 Fateh-Moghadam A, Stieber P. Sensible use of tumor markers.. Basel, Switzerland: Roch; 1993
  • 6 Kimura N, Ghandur-Mnaymen L. An Immunohistochemical study of keratin, carcinoembriyonic antigen, human chorionic gonadotropin and alpha-feto protein in lung cancer. Tohoku J. Exp Med 1985; 145: 23-38.
  • 7 Nöda Y, Simodaira M, Ito H. Two cases of HCG producing large cell carcinoma accompanied with gynecomastia. Nippon Kyobu Gakkai. Zasshi 1990; 28: 781-5.
  • 8 Fukuda M, Sasaki Y, Morita M. Large cell carcinoma of the lung secreting HCG which responded to combination chemotherapy: case report. Jpn J Cli. Oncol 1990; 20: 299-305.
  • 9 Yoshimura M, Nishimura R, Murotani A. Assesment of urinary beta-core fragment of human chorionic gonadotropin as a new tumor marker of lung cancer. Cancer 1994; 73: 2745-52.
  • 10 Huang SC, Hsieh CY, Hwang JL, Ouyang PC, Chen HC. Free alpha subunit of HCG in women with non-trophoblastic tumors. Taiwan I. Hsueh. Hui Tsa Chih 1989; 88: 218-25.
  • 11 Colomer R, Ruibal A, Genolla J, Salvador L. Circulating CA 15-3 levels in non-mammary malignencies. Br. J. Cancer 1989; 59: 283-6.