Biomarkers of bone metabolism in horses: Ante-mortem versus post-mortem correlation in serum and aqueous humour

S. R. McClure; L. T. Glickman; N. W. Glickman; E. S. Rasmussen; S. J. Carlson; G. J. Breur

doi:10.1055/s-0038-1632716

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 2002; 15(02): 67-71
DOI: 10.1055/s-0038-1632716

Original Research

Schattauer GmbH

Biomarkers of bone metabolism in horses: Ante-mortem versus post-mortem correlation in serum and aqueous humour

S. R. McClure

¹Department of Veterinary Clinical Sciences, West Lafayette, IN, USA

,

L. T. Glickman

²Department of Veterinary Pathobiology, West Lafayette, IN, USA

,

N. W. Glickman

³Center for the Human-Animal Bond, School of Veterinary Medicine, Purdue University, West Lafayette, IN, USA

,

E. S. Rasmussen

¹Department of Veterinary Clinical Sciences, West Lafayette, IN, USA

,

S. J. Carlson

¹Department of Veterinary Clinical Sciences, West Lafayette, IN, USA

,

G. J. Breur

¹Department of Veterinary Clinical Sciences, West Lafayette, IN, USA

› Author Affiliations

Abstract

Summary

The objective of this study was to determine the correlation between ante-mortem and 24-hour postmortem concentrations of four markers of bone metabolism in equine serum and aqueous humour. The markers evaluated were osteocalcin, bone alkaline phosphatase, carboxyterminal propeptide of type-1 procollagen and carboxyterminal cross-linked telopeptide of type-1 collagen (ICTP). The concentrations of these markers were poorly correlated (P > 0.05) between aqueous humour and serum. ICTP was the only serum marker significantly correlated (r = 0.93) between ante- and post-mortem samples. ICTP is, therefore, a potential marker for evaluating antemortem markers of bone metabolism in dead horses.

Keywords

Biomarkers - bone metabolism - stress fracture

Full Text

References

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