Download PDF
Methods Inf Med 1997; 36(04/05): 286-289
DOI: 10.1055/s-0038-1636850
Original Article
Schattauer GmbH

Arrhythmia Curve Interpretation Using a Dynamic System Model of the Myocardial Pacemaker

N. Ikeda
1   School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Koshigaya, Saitama, Japan
,
K. Takayanagi
2   Dokkyo University, Koshigaya Hospital, Koshigaya, Saitama, Japan
,
A. Takeuchi
1   School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Koshigaya, Saitama, Japan
,
Y. Nara
1   School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Koshigaya, Saitama, Japan
,
H. Miyahara
1   School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Koshigaya, Saitama, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
19 February 2018 (online)

    Permissions and Reprints

Abstract:

A problem of identifying the phase response curve of the myocardial pacemaker was investigated using a simple dynamic system model of cardiac arrhythmia. A hybrid optimization method of a genetic algorithm and a local optimization technique was employed to obtain a solution of the model fitting. The method was applied to two categories of arrhythmias, ventricular parasystole and high-degree AV block. The present study offered a new insight into the mechanism of cardiac arrhythmias.

Keywords:

Arrhythmia - Phase Response Curve - Ventricular Parasystole - High-degree AV Block
 

  • REFERENCES

  • 1 Jalife J, Moe GK. Effect of electrotonic potentials on pacemaker activity of canine Purkinje fibers in relation to parasystole. Circ Res 1976; 39: 801-8.
    CrossrefPubMedSearch in Google Scholar
  • 2 Ikeda N, Yoshizawa S, Sato T. Difference equation model of ventricular parasystole as an interaction between cardiac pacemakers based on the phase response curve. J Theor Biol 1983; 103: 439-65.
    CrossrefPubMedSearch in Google Scholar
  • 3 Ikeda N. Dynamical system model of genesis of arrhythmias. BME. 1995 09. 60-71 (in Japanese).
    PubMedSearch in Google Scholar
  • 4 Hoshino K, Ikeda N, Tanakadate A, Miyahara H. A computer-based model of parasystolic activity modulated by ventricular activation in the open-chest dog. J Electrocardiol 1989; 22: 277-83.
    CrossrefPubMedSearch in Google Scholar
  • 5 Oreto G, Luzza F, Sattulo G, Arrigo F, Schamroth L. Modulation of atrioventricular junctional parasystole. Am J Cardiol 1986; 57: 694-8.
    CrossrefPubMedSearch in Google Scholar
  • 6 Oreto G, Luzza F, Satullo G, Coglitore S, Schamroth L. Intermittent ventricular bigeminy as an expression of modulated parasystole. Am J Cardiol 1985; 55: 1634-7.
    CrossrefPubMedSearch in Google Scholar
  • 7 Klein HO, Sareli P, Kaplinski E, Schamroth L. Rate-dependent, pacemaker-related, concealed ventricular extrasystoles: Entrainment of an ectopic ventricular focus. Am Heart J 1985; 110: 165-8.
    CrossrefPubMedSearch in Google Scholar
  • 8 Takayanagi K, Inoue T, Sakai Y. Lower pacemaker in high degree atrioventricular block is modulated electronically by atrial excitations. PACE 1991; 14: 1981-5.
    CrossrefPubMedSearch in Google Scholar