Temporal and Spatial Heterogeneity of Blood Supply to the Heart: Visualization and Interpretation

F. Kajiya

doi:10.1055/s-0038-1636878

Methods of Information in Medicine, Table of Contents

Methods Inf Med 1997; 36(04/05): 319-321
DOI: 10.1055/s-0038-1636878

Original Article

Schattauer GmbH

Temporal and Spatial Heterogeneity of Blood Supply to the Heart: Visualization and Interpretation

F. Kajiya

¹Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan

› Author Affiliations

Abstract

Abstract:

Blood flow of the heart muscle (the coronary circulation) exhibits both temporal and spatial heterogeneity. In this paper, the unique blood velocity waveform during a cardiac cycle, the flow fluctuation of a longer period and the within-layer spatial flow heterogeneity of the coronary circulation are described with a reference to the pathogenesis of angina pectoris and myocardial infarction.

Keywords:

Coronary Blood Flow - Heterogeneity of Blood Flow - CCD Microscope - Molecular Tracer

Full Text

References

REFERENCES
1 Kajiya F, Klassen GA, Spaan JAE, Hoffman JIE. Coronary Circulation-basic mechanism and clinical relevance. Springer-Verlag; 1990
2 Yada T, Hiramatsu O, Kimura A, Goto M, Ogasawara Y, Tsujioka K, Yamamori S, Ohno K, Hosaka H, Kajiya F. In vivo observation of subendocardial microvessels of the beating porcine heart using a needle-probe video-microscope with a CCD camera. Circ Res 1993; 72: 939-46.
3 Hiramatsu O, Goto M, Yada T, Kimura A, Tachibana H, Ogasawara Y, Tsujioka K, Kajiya F. Diameters of subendocardial arterioles and venules during prolonged diastoles in canine left ventricles. Circ Res 1994; 75: 393-9.
4 Yada T, Hiramatsu O, Goto M, Ogasawara Y, Kimura A, Yamamoto T, Tsujioka K, Kajiya F. Effects of Nitroglycerin on diameter and pulsation-amplitude of subendocardial arterioles in beating procine heart. Am J Physiol 1994; 36: H1719-H25.
5 Yada T, Hiramatsu O, Kimura A, Tachibana H, Chiba Y, Lu S, Goto M, Ogasawara Y, Tsujioka K, Kajiya F. Direct in vivo observation of subendocardial arteriolar response during reactive hyperemia. Circ Res 1995; 77: 622-31.
6 Ogasawara Y, Toyota E, Hiramatsui O, Tachibana H, Yamamori S, Hosaka H, Kajiya F. In-vivo observation of subendocardial arteriolar blood velocity in dogs by highspeed needle-probe CCD microscope. Circulation. (suppl) (in press).
7 Kimura A, Hiramatsu O, Yamamoto T, Ogasawara Y, Yada T, Goto M, Tsujioka K, Kajiya F. Effect of coronary stenosis on phasic pattern of septal artery in the dog. Am J Physiol 1992; 262: H1690-H8.
8 Goto M, Flynn AE, Doucette JW, Kimura A, Hiramatsu O, Yamamoto T, Ogasawara Y, Tsujioka K, Hoffman JIE, Kajiya F. Effect of intracoronary nitroglycerin administration on phasic pattern and transmural distribution of flow during coronary artery stenosis. Circulation 1992; 85: 2296-2304.
9 Sestier FJ, Mildenberger RR, Klassen GA. Role of autoregulation in spatial and temporal perfusion heterogeneity of canine myocardium. Am J Physiol 1978; 235: H64-H71.
10 Matsumoto T, Goto M, Tachibana H, Ogasawara Y, Tsujioka K, Kajiya F. Microheterogeneity of myocardial blood flow in rabbit hearts during normoxic and hypoxic states. Am J Physiol 1996; 39: H435-H41.