Novel Anticoagulant Treatment for Pulmonary Embolism with Direct Oral Anticoagulants Phase 3 Trials and Clinical Practice

Cécile Tromeur; Liselotte M. van der Pol; Albert T.A. Mairuhu; Christophe Leroyer; Francis Couturaud; Menno V. Huisman; Frederikus A. Klok

doi:10.1055/s-0038-1642622

Seminars in Interventional Radiology, Table of Contents

Semin intervent Radiol 2018; 35(02): 83-91
DOI: 10.1055/s-0038-1642622

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Novel Anticoagulant Treatment for Pulmonary Embolism with Direct Oral Anticoagulants Phase 3 Trials and Clinical Practice

Cécile Tromeur

¹Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands

²Department of Internal Medicine and Chest Diseases, Groupe d'Etude de la Thrombose de Bretagne Occidentale, Equipe d'Accueil 3878, Hôpital de la Cavale Blanche, CHRU, Brest, France

³Centre d'Investigation Clinique INSERM 1412, University of Brest, Brest, France

,

Liselotte M. van der Pol

¹Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands

⁴Department of Internal Medicine, Haga Teaching Hospital, The Hague, The Netherlands

,

Albert T.A. Mairuhu

⁴Department of Internal Medicine, Haga Teaching Hospital, The Hague, The Netherlands

,

Christophe Leroyer

²Department of Internal Medicine and Chest Diseases, Groupe d'Etude de la Thrombose de Bretagne Occidentale, Equipe d'Accueil 3878, Hôpital de la Cavale Blanche, CHRU, Brest, France

³Centre d'Investigation Clinique INSERM 1412, University of Brest, Brest, France

,

Francis Couturaud

²Department of Internal Medicine and Chest Diseases, Groupe d'Etude de la Thrombose de Bretagne Occidentale, Equipe d'Accueil 3878, Hôpital de la Cavale Blanche, CHRU, Brest, France

³Centre d'Investigation Clinique INSERM 1412, University of Brest, Brest, France

,

Menno V. Huisman

¹Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands

,

Frederikus A. Klok

¹Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands

› Author Affiliations

Abstract

Anticoagulant therapy is the cornerstone of therapeutic management in acute venous thromboembolism (VTE), consisting of pulmonary embolism and deep vein thrombosis. Direct oral anticoagulants (DOACs) have become the standard of care because of their good safety profile and ease of use in clinical practice. Indeed, phase 3 randomized trials (AMPLIFY, EINSTEIN, RECOVER, and HOKUSAI studies) showed that DOACs provided a similar efficacy and a better safety than conventional treatment with parenteral heparin with overlapping loading dose of vitamin K antagonists in acute VTE therapeutic management. The results of published data from real-world registries confirm the safety and efficacy of DOACs demonstrated in the phase 3 trials.

Keywords

venous thromboembolism - DOAC - pulmonary embolism - deep venous thrombosis - anticoagulant - interventional radiology

Full Text

References

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