Immunoreactive Factor VIII in Carriers of Hemophilia A+ and A-

K Lechner

doi:10.1055/s-0038-1647767

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 29(02): 240-246
DOI: 10.1055/s-0038-1647767

Original Article

Schattauer GmbH

Immunoreactive Factor VIII in Carriers of Hemophilia A⁺ and A^-

K Lechner

¹Central Coagulation Laboratory, First Department of Medicine, University of Vienna, Austria

› Author Affiliations

Abstract

Summary

Factor VIII activity and inhibitor-neutralizing capacity of plasmas of 30 probable or definite carriers of hemophilia A were compared. The inhibitor-neutralization test is less useful to recognize the carrier-state than the factor VIII assay. Plasmas of two carriers belonging to families (in which, in at least one member, the diagnosis of hemophilia A+ was established) had an inhibitor neutralizing capacity twice as high as expected from the biological activity, while 28 carriers from hemophilia A^- families had an inhibitor neutralizing-capacity equivalent to their factor VIII activity.

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References

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