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Thromb Haemost 1973; 29(02): 247-252
DOI: 10.1055/s-0038-1647768
DOI: 10.1055/s-0038-1647768
Original Article
Studies on the Prolonged Prothrombin Time in Haemophilia BM
Further Information
Publication History
Received
05 February 1973
Publication Date:
30 June 2018 (online)
Summary
Prolonged prothrombin time was measured in four haemophilia B patients with the aid of bovine or rat thromboplastins, whereas normal values were obtained when human or rabbit thromboplastin was used. The anomaly can be ascribed to the decreased level of factor VII. Four carrier relatives exhibited normal prothrombin time independent of the source of thromboplastin. The prolonged prothrombin time appears to be a non-hereditary phenomenon and it may be attributed to a species- specific interaction between thromboplastin of diverse sources and human factor VII, rather than to anomalous factor IX.
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References
- 1 Biggs R, Douglas A. S. 1953; The measurement of prothrombin in plasma. Journal of Clinical Pathology 06: 15.
- 2 Biggs R, Macfarlane R. G. 1962. Human Blood Coagulation and its Disorders. Blackwell Scientific Publications; Oxford.:
- 3 Brown P. E, Hougie C, Roberts H. R. 1970; The genetic heterogeneity of haemophilia B. New England Journal of Medicine 283: 61.
- 4 Denson K. W. E, Biggs R, Mantjcci P. M. 1968; An investigation on three patients with Christmas disease due to an abnormal type of factor IX. J ournal of Clinical Pathology 21: 160.
- 5 Elödi S, Puskâs E. 1972; Variants of haemophilia. B. Thrombosis et Diathesis Haemorrhagica 28: 489.
- 6 Gray G. R, Teasdale J. M, Thomas J. W. 1968; Haemophilia BM . Canadian Medical Association Journal 98: 552.
- 7 Hougie C, Twomey J. J. 1967; Haemophilia BM: a new type of factor IX deficiency. Lancet 01: 698.
- 8 Meyer D, Larrieu M. J. 1971; Factor VIII and IX variants. Relationship between haemophilia BM and haemophilia BM . European Journal of Clinical Investigation 01: 425.
- 9 Meyer D, Bidwell E, Larrieu M. J. 1972; Cross reacting material in genetic variants of haemophilia B. J ournal of Clinical Pathology 25: 433.
- 10 Minami J. Y, Kasper C. K, Rapaport S. I. 1969; Incidence of hemophilia B variants. Clinical Research 27: 116.
- 11 Pfueller S, Somer J. B, Castaldi P. A. 1969; Haemophilia B due to an abnormal factor IX. Coagulation 02: 213.
- 12 Twomey J. J, Corless J, Thornton L, Hougie C. 1969; Studies on the inheritance and nature of haemophilia BM . American Journal of Medicine 46: 372.