On the Mechanism by which Bovine Fibrinogen Induces the Release and Availability Reaction of Human Blood Platelets

P Kubisz; J Suranová

doi:10.1055/s-0038-1647782

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 29(02): 416-433
DOI: 10.1055/s-0038-1647782

Original Article

Schattauer GmbH

On the Mechanism by which Bovine Fibrinogen Induces the Release and Availability Reaction of Human Blood Platelets

P Kubisz

¹Hemostasis Laboratory, Department Hospital, Čadca, Czechoslovakia

,

J Suranová

¹Hemostasis Laboratory, Department Hospital, Čadca, Czechoslovakia

› Author Affiliations

Abstract

Summary

Bovine fibrinogen can aggregate human blood platelets by a direct mechanism (first wave) and also indirectly by releasing endogenous ADP (second wave).

A primarily non-altered surface structure of the thrombocytes is important for the induction of the first wave.

Under certain conditions a second aggregation wave, concomitant with the release and the availability reaction is elicited.

Besides the cells’ contact, the presence of ADP and calcium ions are necessary for the induction of the release reaction in human platelet rich plasma.

The changes induced by bovine fibrinogen thus follow the same pattern as the irreversible phase of aggregation, linked to release as induced by ADP.

Full Text

References

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