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Thromb Haemost 1973; 29(03): 598-602
DOI: 10.1055/s-0038-1647801
Original Article
Schattauer GmbH

Plasminogen Depletion during Administration of Epsilon-aminocaproic Acid

D. W Nibbelink
1   Departments of Neurology and Pathology, University of Iowa, Iowa City, Iowa 52240, U.S.A
,
C. D Jacobsen
1   Departments of Neurology and Pathology, University of Iowa, Iowa City, Iowa 52240, U.S.A
› Author Affiliations
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Publication History

Publication Date:
24 July 2018 (online)

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Summary

Sixteen patients with acute onset subarachnoid hemorrhage were treated with intravenous administration of epsilon-aminocaproic acid. This drug inhibits activation of plasminogen and, to some extent, the effect of plasmin as well. In this study a marked decrease in immunological quantities of plasminogen was observed. This depletion of plasminogen occurred without concommitant quantitative changes in platelets or fibrinogen. Hence, the antiftbrinolytic effect of epsilon-aminocaproic acid is not only through inhibition of plasminogen activation and of plasmin itself, but also through a marked reduction in plasminogen.

This study was supported by NINDS Grant No. NS09431.


 

  • References

  • 1 Ablondi F. B, Hagen J. J, Philips M, de Renzo E. C. 1959; Inhibition of plasmin, trypsin, and streptokinase-activated fibrinolytic system by epsilon-aminocaproic acid. Archives of Biochemistry and Biophysics 82: 153.
    CrossrefPubMedSearch in Google Scholar
  • 2 Alkjaersig N, Fletcher A. P, Sherry S. 1958; Epsilon-aminocaproic acid: an inhibitor of plasminogen activation. Journal of Biological Chemistry 234: 832.
    PubMedSearch in Google Scholar
  • 3 Clarke H GM, Freeman T. 1968; Quantitative immunoelectrophoresis of human serum proteins. Clinical Science 35: 403.
    PubMedSearch in Google Scholar
  • 4 Gibbs J. R, O’Gorman P. 1967; Fibrinolysis in subarachnoid hemorrhage. Postgraduate Medical Journal 43: 779.
    CrossrefPubMedSearch in Google Scholar
  • 5 Jacobsen C. D. 1968; Proteolytic Capacity in Human Plasma. Part I: Measurement of proteolytic activity in the presence of natural inhibitors and study of the inter-individual variations. Scandinavian Journal of Clinical Laboratory Investigation 21: 216.
    PubMedSearch in Google Scholar
  • 6 Jacobsson K. 1955; Studies on the determination of fibrinogen in human blood plasma. Scandinavian Journal of Clinical Laboratory Investigation, Suppl 14: 7.
    PubMedSearch in Google Scholar
  • 7 Mancini G, Carbonara A. O, Heremans J. F. 1965; Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 02: 235.
    CrossrefPubMedSearch in Google Scholar
  • 8 Merskey C, Yolezari P, Johnson A. J. 1969; A rapid simple sensitive method for measuring fibrinolytic split products in human serum. Proceedings for the Society of Experimental Biology and Medicine 131: 871.
    PubMedSearch in Google Scholar
  • 9 Mttllan S, Dawley J. 1968; Antifibrinolytic therapy for intracranial aneurysms. Journal of Neurosurgery 28: 21.
    CrossrefPubMedSearch in Google Scholar
  • 10 Nibbelink D. W. 1971; Antifibrinolytic activity during administration of epsilon-aminocaproic acid. Stroke 02: 555.
    CrossrefPubMedSearch in Google Scholar
  • 11 Rabiner S. F, Goldfine I. D, Hart A, Summoria L, Robbins K. C. 1969; Radioimmunoassay of human plasminogen and plasmin. Journal of Laboratory and Clinical Medicine 74: 265.
    PubMedSearch in Google Scholar
  • 12 Wu K. K, Jacobsen C. D, Hoak J. C. 1973 Highly sensitive method for the assay of plasminogen. Journal of Laboratory and Clinical Medicine. in press..
    PubMedSearch in Google Scholar