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Thromb Haemost 1976; 35(02): 350-357
DOI: 10.1055/s-0038-1647928
Original Article
Schattauer GmbH

Increased Protein Synthesis by Human Platelets during Phagocytosis of Latex Particles in Vitro

Hana Bessler
1   Department of Medicine “B” and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, and Tel-Aviv University Medical School, Israel
,
Galila Agam
1   Department of Medicine “B” and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, and Tel-Aviv University Medical School, Israel
,
Meir Djaldetti   *
1   Department of Medicine “B” and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, and Tel-Aviv University Medical School, Israel
› Author Affiliations
Further Information

Publication History

Received 22 June 1975

Accepted 18 August 1975

Publication Date:
02 July 2018 (online)

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Summary

A three-fold increase of protein synthesis by human platelets during in vitro phagocytosis of polystyrene latex particles was detected. During the first two hours of incubation, the percentage of phagocytizing platelets and the number of latex particles per platelet increased; by the end of the third hour, the first parameter remained stable, while the number of latex particles per cell had decreased.

Vincristine (20 μg/ml of cell suspension) inhibited platelet protein synthesis. This effect was both time- and dose-dependent. The drug also caused a decrease in the number of phagocytizing cells, as well as in their phagocytotic activity.

* Established investigator of the Chief Scientist’s Bureau, Ministry of Health.


 

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