Increased Protein Synthesis by Human Platelets during Phagocytosis of Latex Particles in Vitro

Hana Bessler; Galila Agam; Meir Djaldetti

doi:10.1055/s-0038-1647928

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1976; 35(02): 350-357
DOI: 10.1055/s-0038-1647928

Original Article

Schattauer GmbH

Increased Protein Synthesis by Human Platelets during Phagocytosis of Latex Particles in Vitro

Hana Bessler

¹Department of Medicine “B” and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, and Tel-Aviv University Medical School, Israel

,

Galila Agam

¹Department of Medicine “B” and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, and Tel-Aviv University Medical School, Israel

,

Meir Djaldetti^*

¹Department of Medicine “B” and Hematology Clinic, Hasharon Hospital, Petah-Tiqva, and Tel-Aviv University Medical School, Israel

› Institutsangaben

Abstract

Summary

A three-fold increase of protein synthesis by human platelets during in vitro phagocytosis of polystyrene latex particles was detected. During the first two hours of incubation, the percentage of phagocytizing platelets and the number of latex particles per platelet increased; by the end of the third hour, the first parameter remained stable, while the number of latex particles per cell had decreased.

Vincristine (20 μg/ml of cell suspension) inhibited platelet protein synthesis. This effect was both time- and dose-dependent. The drug also caused a decrease in the number of phagocytizing cells, as well as in their phagocytotic activity.

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Referenzen

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