Chemorheological Studies of the Effect of Heparin on the Course of Coagulation

K. A Overholser; C. B Baysinger; T. R Harris; T Deveau

doi:10.1055/s-0038-1647977

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1976; 35(02): 447-459
DOI: 10.1055/s-0038-1647977

Original Article

Schattauer GmbH

Chemorheological Studies of the Effect of Heparin on the Course of Coagulation

K. A Overholser^*

¹Departments of Chemical and Biomedical Engineering, School of Engineering and Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, U. S. A.

,

C. B Baysinger

¹Departments of Chemical and Biomedical Engineering, School of Engineering and Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, U. S. A.

,

T. R Harris

¹Departments of Chemical and Biomedical Engineering, School of Engineering and Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, U. S. A.

,

T Deveau

¹Departments of Chemical and Biomedical Engineering, School of Engineering and Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, U. S. A.

› Institutsangaben

Abstract

Summary

The influence of sodium heparin on viscoelastic change during coagulation was determined in vitro for whole blood samples from ten normal subjects at heparin concentrations ranging from 0 to 1.45 units/(ml whole blood). A four-parameter chemorheological model was used to describe the time course of coagulation as measured by the Weissenberg Rheogoniometer. One parameter compares closely with the whole blood activated partial thromboplastin time, while the other three may be related to the chemical kinetics of clotting.

The chemorheological model and experimental techniques were then tested in a dog preparation. It was found that rheological measurements are more self-consistent than either thrombelastography or the activated partial thromboplastin time for the assay of in vivo heparin in two dogs.

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Referenzen

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