Inhibition of Human and Animal Platelet Adhesiveness to Glass Bead Columns by Adenosine, Dipyridamole, Chlorpromazine and Acetylsalicylic Acid

Buichi Fujttani; Toshimichi Tsuboi; Kazuko Takeno; Kouichi Yoshida; Masanao Shimizu

doi:10.1055/s-0038-1648055

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 36(02): 401-410
DOI: 10.1055/s-0038-1648055

Original Article

Schattauer GmbH

Inhibition of Human and Animal Platelet Adhesiveness to Glass Bead Columns by Adenosine, Dipyridamole, Chlorpromazine and Acetylsalicylic Acid

Buichi Fujttani

¹Research Laboratory, Dainippon Pharmaceutical Co., Ltd., Japan Enoki 33–94, Suita, Osaka 564

,

Toshimichi Tsuboi

¹Research Laboratory, Dainippon Pharmaceutical Co., Ltd., Japan Enoki 33–94, Suita, Osaka 564

,

Kazuko Takeno

¹Research Laboratory, Dainippon Pharmaceutical Co., Ltd., Japan Enoki 33–94, Suita, Osaka 564

,

Kouichi Yoshida

¹Research Laboratory, Dainippon Pharmaceutical Co., Ltd., Japan Enoki 33–94, Suita, Osaka 564

,

Masanao Shimizu

¹Research Laboratory, Dainippon Pharmaceutical Co., Ltd., Japan Enoki 33–94, Suita, Osaka 564

› Author Affiliations

Abstract

Summary

The differences among human, rabbit and guinea-pig platelet adhesiveness as for inhibitions by adenosine, dipyridamole, chlorpromazine and acetylsalicylic acid are described, and the influence of measurement conditions on platelet adhesiveness is also reported. Platelet adhesiveness of human and animal species decreased with an increase of heparin concentrations and an increase of flow rate of blood passing through a glass bead column. Human and rabbit platelet adhesiveness was inhibited in vitro by adenosine, dipyridamole and chlorpromazine, but not by acetylsalicylic acid. On the other hand, guinea-pig platelet adhesiveness was inhibited by the four drugs including acetylsalicylic acid. In in vivo study, adenosine, dipyridamole and chlorpromazine inhibited platelet adhesiveness in rabbits and guinea-pigs. Acetylsalicylic acid showed the inhibitory effect in guinea-pigs, but not in rabbits.

Full Text

References

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