Effect of Aspirin on Platelet Phospholipids

Summary

It was observed that the acetylsalicylic acid “in vitro” (final concentration 10⁻⁴ M) as well as “in vivo” (1 g of aspirin) caused a platelet phospholipids variation which basically consisted of:

1. A diminution of the phospholipids/proteins rate of 22%.

2. A reduction of sphingomyelin “in vivo” of 27.66% and “in vitro” of 16.82%.

3. An increase in phosphatidyl choline “in vivo” of 12.24% and “in vitro” 10.28%.

The possible effects that these changes might have on the platelet function are evaluated.

• References

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