Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1972; 27(01): 019-024DOI: 10.1055/s-0038-1649005 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH Immune Reactive Factor IX in Acquired Factor IX Deficiency[*] K Lechner 1 First Department of Medicine, University of Vienna, Austria (Head: Prof. Dr. E. Deutsch) › Author Affiliations Recommend Article Abstract Buy Article Summary Factor IX-antibody-neutralizing material has been estimated in plasmas of patients with acquired factor IX deficiency. In patients with liver cirrhosis and patients who had been treated with L-Asparaginase the plasma neutralized an amount of antibody expected from the biological activity. In patients treated with phenprocoumon and in one patient with biliary obstruction an excess of factor IX-antibody neutralizing material was found. This inactive factor IX probably represents a precursor molecule of factor IX. Full Text References References 1 Denson K. W. E, Biggs R, Haddon M. E, Borrett R, Cobb K. Two types of haemophilia (A+ and A-): A study of 48 cases. Brit. J. Haemat 17: 163 1969; 2 Deutsch E, Fischer M, Frischauf H, Honetz N, Lechner K, Pesendorfer F, Stych H, Weissmann A. Blood coagulation changes under L-Asparaginase therapy. In: Recent results in cancer research: Experimental and clinical effects of L-asparaginase. Edited Grundmann E, Oettgen H. F. 331 Springer-Verlag; Berlin - Heidelberg - New York: 1970 3 Grundmann E. Grundlagen der L-Asparaginase-Therapie. In: Chemo- und Immunothérapie der Leukosen und malignen Lymphome. Ed. Stacker A. 23 Bohmann, Wien: 1969 4 Goodnight S. H, Feinstein D. I, Osterud B, Rapaport S. I. Factor VII antibodyneutralizing material in hereditary and acquired factor VII deficiency. Blood 28: 1 1971; 5 Hemher H. G, Veitkamp J. J, Hensen A, Loeliger E. A. Nature of prothrombin biosynthesis: Preprothrombinaemia in vitamin K-deficiency. Nature (Lond) 200: 589 1963; 6 Hemher H. C, Muller A. D. Kinetic aspects of the interaction of blood clotting enzymes V. The reaction mechanism of the extrinsic coagulation system as revealed by the kinetics of one- stage estimations of coagulation enzymes. Thrombos. Diathes. haemorrh. (Stuttg) 19: 368 1968; 7 Hemher H. V, Veitkamp J. J, Loeliger E. A. Kinetic aspects of the interaction of blood enzymes, III. The reaction mechanism of the extrinsic clotting system as revealed by the kinetics of one-stage estimations of coagulation enzymes. Thrombos. Diathes. haemorrh. (Stuttg) 19: 346 1968; 8 Hemher H. G, Muller A. D, Loeliger E. A. Preliminary reports: Two types of prothrombin in vitamin K-deficiency. Thrombos. Diathes. haemorrh. (Stuttg) 23: 633 1970; 9 Hoyer L. W, Breckenridge R. T. Immunologic studies of anti-hemophilic factor (AHF, factor VIII): Cross-reacting material in a genetic variant of hemophilia A. Blood 32: 962 1968; 10 Josso F, Lavergne J. M, Gouault M, Prou-Wartelle O, Soulier J. P. Différents états moléculaires du facteur II (prothrombine). Leur étude à l’aide de la staphylocoagulase et d’anticorps anti-facteur II. I. Le facteur II chez les sujets traités par les antagonistes de la vitamine K. Thrombos. Diathes. haemorrh. (Stuttg) 20: 88 1968; 11 Larrieu M. J, Meyer D. Abnormal factor IX during anticoagulant treatment. Lancet 02: 1085 1970; 12 Lechner K. Factor IX-inhibitors. Report of two cases and a study of the biological, chemical and immunological properties of the inhibitors. Thrombos. Diathes. haemorrh. (Stuttg) 25: 447 1971; 13 Meyer D, Dreyfus M, Larrieu M. J. Inactive factor IX during anticoagulant treatment. Second conference thrombosis and haemostasis; Oslo: 1971 14 Prentice G. M. Panel discussion. The International Society on Thrombosis and Haemostasis; Montreux, Switzerland: Juli 29 - August 1, 1970 15 Prydz H. The mode of action of peroral anticoagulants. Abstr. XIII Internat. Congr. Hematol., Munich. 1970: 70. 16 Prydz H, Gladhaug A. Factor X. Immunological Studies. Thrombos. Diathes. haemorrh. (Stuttg) 25: 157 1971; 17 Roberts H. R, Grizzle J. E, McLester W. D. et al. Genetic variants of hemophilia B: detection by means of a specific PTC inhibitor. J. clin. Invest 47: 360-365. 1968; 18 Veltkamp J. J, Muis H, Muller A. D, Hemker H. G, Loeliger E. A. Additional evidence for the existence of a precursor molecule of the prothrombin complex in oral anticoagulation. Thrombos. Diathes. haemorrh. (Stuttg) 25: 312 1971; 19 Zimmerman T. S, Ratnojf O. D, Powell A. E. The immunologic differentiation of the antihemophilic factor (factor VIII) abnormalities in classic hemophilia and von Willebrand’s disease. J. clin. Invest 49: 106a 1970;
