Thromb Haemost 1972; 28(02): 299-305
DOI: 10.1055/s-0038-1649011
Original Article
Schattauer GmbH

Fibrinolysis by Bile

Burnham J. King
1   Department of Haematology, Groote Schuur Hospital and University of Cape Town Observatory, Cape Province, South Africa
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Further Information

Publication History

Publication Date:
29 June 2018 (online)

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Summary

Fibrinolytic activity is described in the bile of man and of several species of mammal. This activity can be precipitated from whole bile by ammonium sulphate, by acetone, and by a chlor of orm/methanol partition technique. It behaves as an anion at pH 7.4. Ammonium sulphate precipitated bile is caseinolytic, and fibrinolytic on a heated fibrin plate. It gives a peak of fibrinolytic activity on column chromatography with sephadex G50 at Kav = 0.3, suggesting a molecular weight of ± 15,000.