Effect of Detergents on Platelet Electrophoresis and Aggregation, and the Possible Relation of Plasma Surface Activity to Thrombosis

J. P Hampton; D. G Nicholls

doi:10.1055/s-0038-1649024

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1972; 28(03): 408-418
DOI: 10.1055/s-0038-1649024

Original Article

Schattauer GmbH

Effect of Detergents on Platelet Electrophoresis and Aggregation, and the Possible Relation of Plasma Surface Activity to Thrombosis

J. P Hampton

,

D. G Nicholls

¹Department of Medicine, Nottingham University, England

› Institutsangaben

Abstract

Summary

A variety of anionic, cationic, and non-ionic detergent compounds has been shown to increase the sensitivity of the electrophoretic response of human platelets to adenosine diphosphate. The effect of such compounds on normal platelets is very similar to that of plasma from patients with arterial disease, and it is suggested that there may be an abnormality in the surface-active properties of the plasma from such patients. One detergent, cetyl pyridinium chloride, was found not to induce any change in platelet electrophoretic behaviour, but to protect platelets from other detergents. It was also shown to be a powerful inhibitor of platelet aggregation.

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Referenzen

References
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