The Estimation of Blood Platelet Survival

E. A Murphy; M. E Francis; J. F Mustard

doi:10.1055/s-0038-1649028

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 28(03): 447-456
DOI: 10.1055/s-0038-1649028

Original Article

Schattauer GmbH

The Estimation of Blood Platelet Survival

IV. Characteristics of the Residual Errors from Regression

Authors

E. A Murphy

¹Departments of Medicine and Biostatistics, Johns Hopkins University School of Medicine, Baltimore, Md. 21205, U.S.A. and the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada
M. E Francis

¹Departments of Medicine and Biostatistics, Johns Hopkins University School of Medicine, Baltimore, Md. 21205, U.S.A. and the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada
J. F Mustard

¹Departments of Medicine and Biostatistics, Johns Hopkins University School of Medicine, Baltimore, Md. 21205, U.S.A. and the Department of Pathology, Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada

Abstract

Summary

The characteristics of experimental error in measurement of platelet radioactivity have been explored by blind replicate determinations on specimens taken on several days on each of three Walker hounds.

Analysis suggests that it is not unreasonable to suppose that error for each sample is normally distributed ; and while there is evidence that the variance is heterogeneous, no systematic relationship has been discovered between the mean and the standard deviation of the determinations on individual samples. Thus, since it would be impracticable for investigators to do replicate determinations as a routine, no improvement over simple unweighted least squares estimation on untransformed data suggests itself.

Full Text

References

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