Blood Coagulation and Fibrinolysis in a Random Sample of 788 Men 54 Years Old

Kristoffer Korsan-Bengtsen; Lars Wilhelmsen; Gösta Tibblin

doi:10.1055/s-0038-1649044

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 28(01): 089-098
DOI: 10.1055/s-0038-1649044

Original Article

Schattauer GmbH

Blood Coagulation and Fibrinolysis in a Random Sample of 788 Men 54 Years Old

I. Correlations between the Variables of Clotting and Fibrinolysis

Kristoffer Korsan-Bengtsen

¹From Medical Departments I and II, Sahlgren’s Hospital, University of Göteborg, Göteborg, Sweden

,

Lars Wilhelmsen

¹From Medical Departments I and II, Sahlgren’s Hospital, University of Göteborg, Göteborg, Sweden

,

Gösta Tibblin

¹From Medical Departments I and II, Sahlgren’s Hospital, University of Göteborg, Göteborg, Sweden

› Author Affiliations

Abstract

Summary

Blood coagulation and fibrinolysis have been studied in a randomly selected population of 788 men 54 years of age. The mean values, standard deviations and distributions of recalcified plasma clotting time, PTT in silicone tubes and glass tubes, factor II-VII-X activity, factor VIII, fibrinogen, fibrinolytic activity in an euglobulin precipitation and plasminogen are presented. Linear regression analyses between the variables have been carried out. It was found that there is a significant correlation between fibrinogen and PTT in silicone tubes. An increased fibrinogen concentration thus tends to give prolonged clotting times. Factor VIII is negatively correlated to recalcified plasma clotting time and PTT in glass and silicone tubes. Increased factor VIII levels thus tend to shorten the clotting times. There is also a slight negative correlation between factor II-VII-X activity and PTT in glass tubes. In evaluating the significance of prolonged or shortened clotting times the inverse influence of fibrinogen and factor VIII on clotting time has to be considered. This is especially important in situations with increased frequency of thrombosis where both fibrinogen and factor VIII often are increased.

Full Text

References

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