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Thromb Haemost 1973; 30(02): 272-279
DOI: 10.1055/s-0038-1649074
Original Article
Schattauer GmbH

Tranexamic Acid in the Control of Spontaneous Bleeding in Severe Haemophilia

S. G Rainsford
1   Lord Mayor Treloar Hospital, Alton, Hampshire, and Kabi Pharmaceuticals Limited, Ealing, London
,
A. J Jouhar
1   Lord Mayor Treloar Hospital, Alton, Hampshire, and Kabi Pharmaceuticals Limited, Ealing, London
,
Angela Hall
1   Lord Mayor Treloar Hospital, Alton, Hampshire, and Kabi Pharmaceuticals Limited, Ealing, London
› Author Affiliations
Further Information

Publication History

Received for publication 30 March 1973

Accepted for publication 12 June 1973

Publication Date:
30 June 2018 (online)

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Summary

A double-blind cross-over study of the prophylactic value of tranexamic acid (“Cyklokapron”), in a dose of 3.0 g per day, against spontaneous bleeding episodes in severe haemophilia was undertaken. Records of bleeding episodes were maintained during therapy in twenty boys with confirmed clinical severity, over two school terms. A significant reduction (p <0.05) in spontaneous bleeding episodes was attained with an associated lessening in the transfusion requirement of therapeutic material, and without obvious side effects. Recommendations are made for further investigations.

 

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