Summary
This work makes an attempt to display the behaviour of portal clotting time after
intraduodenal administration of heparin. The experiments were carried out in 20 cats,
which were divided into two groups.
In the first stage of investigation the normal clotting time was determined in portal
vein and caudal vena cava. Afterwards the same parameters were investigated after
intraduodenal administration of heparin or saline solution.
It was shown that after intraduodenal administration of heparin the clotting time
in portal vein in each case was prolongated, but in the caudal vena cava it remains
normal. After intraduodenal administration of saline solution the clotting time in
both portal vein and caudal vena cava was unchanged.
Conclusions. 1. In the performed experiments the heparin administered intraduodenally passes from
the small intestine into the collection of the portal vein. 2. The lack of anticoagulative
activity of the heparin given intraduodenally in the blood of the peripheral veins
probably caused by a block present above the portal collection.
