Measurement of the Rate of Clot Retraction

Michio Itoh; Yoshihisa Nishimura; Osamu Takenaka; Yuji Inada

doi:10.1055/s-0038-1649185

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1974; 31(03): 452-456
DOI: 10.1055/s-0038-1649185

Original Article

Schattauer GmbH

Measurement of the Rate of Clot Retraction

Authors

Michio Itoh

¹Laboratory of Biological Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan
Yoshihisa Nishimura

¹Laboratory of Biological Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan
Osamu Takenaka

¹Laboratory of Biological Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan
Yuji Inada

¹Laboratory of Biological Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan

Abstract

Summary

The volume of serum exuded from clot was measured with time in the presence of platelets. The change of the volume of clot followed the first order kinetics with respect to time and the rate constant (k) was introduced to assay for clot retraction. The value of k and maximal serum volume exuded from clot, Vf, are dependent on the number of platelets, but the way k depends on the number of platelets is different from that Vf does on it. This suggests that these two parameters reflect the different phases of clot retraction.

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References

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