Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1966; 15(03/04): 554-560DOI: 10.1055/s-0038-1649458 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH The Kidneys and the Liver as the Organs Regulating the Fibrinolytic System of the Circulating Blood[*] Authors Author Affiliations T Januszko 1 Department of General and Experimental Pathology School of Medicine, Bialystole – Poland (Head: Prof. Karol Buluk) M Furman 1 Department of General and Experimental Pathology School of Medicine, Bialystole – Poland (Head: Prof. Karol Buluk) K Buluk 1 Department of General and Experimental Pathology School of Medicine, Bialystole – Poland (Head: Prof. Karol Buluk) Recommend Article Abstract Buy Article(opens in new window) Summary In experiments on rabbits it was shown by means of interruption and reestablishment of hepatic and renal circulation that these organs play an essential role in the regulation of the fibrinolytic system of the circulating blood. The kidneys are the source of the plasminogen activator secreted in the blood whereas the liver is responsible for the inactivation of the fibrinolytic system. Full Text References References 1 Buluk K, Furman M. On the controlling function of the kidneys in fibrinolysis. Experientia (Basel) 18: 146 1962; 2 Buluk K, Malofiejew M. Preparation of fibrinolysis activator in the extracorporal kidney. Acta physiol, pol 14: 351 1963; 3 Dorobisz T, Janiakowa A. Ostry zespôl fibrynolityczny w przebiegu operacji w zwi¹zku z marskoœci¹ w¹troby. Pol. Tyg. lek 17: 639 1962; 4 Fearnley G. R. Plasma fibrinolytic activity in cirrhosis of the liver. Lancet 270: 450 1956; 5 Fletcher A. P, Biederman O, Moore D, Alkjaersig N, Sherry S. Abnormal plasminogenplasmin system activity (fibrinolysis) in patients with hepatic cirrhosis: its cause and consequences. J. clin. Invest 43: 681 1964; 6 Furman M. Aktywacja fibrynolizy krwi kr¹z¹cej królika. Roczn. Akad. Med. Marchlewskiego 09: 373 1963; 7 Grossi C. E, Rousselot L. M, Panke W. F. Control of fibrinolysis during portacaval shunts. JAMA 187: 1005 1964; 8 Jürgens J, Beller F. K. Klinische Methoden der Blutgerinnungsanalyse. Thieme, Stuttgart: 1959 9 Kwaan H. G, McFadzean A. J. S, Gook J. Plasma fibrinolytic activity in cirrhosis of the liver. Lancet 270: 132 1956; 10 Marchai G, Frileux C. L, Bilski-Pasquier G, Weiss M, Cornet P, Samama M, Larrieu M. Fibrinolyse mortelle au cours d’une anastomose porto-cave pour cirrhose compliquée d’hématémèses récidivantes. Presse méd 67: 1851 1959; 11 de Nicola P, Soardi F. Fibrinolysis in liver diseases. Study of 109 cases by means of the fibrin plate method. Thrombos. Diathes. haemorrh. (Stuttg) 02: 290 1958; 12 Niewiarowski S, Prokopowicz J, Poplawski A, Worowski K. Inhibition of dog fibrinolytic system in experimental tubular necrosis of kidney. Experientia (Basel) 20: 101 1964; 13 Nolf P, Adant M. De l’intervention du foie dans les phénomènes de la coagulation du sang. Sang 02: 257 1951; 14 Perlick E. Hämorrhagische Diathesen. VEB Georg Thieme, Leipzig: 1962 15 Phillips L. L, Skrodelis V. The fibrinolytic enzyme system in normal, hemorrhagic and disease states. J. clin. Invest 37: 965 1958; 16 Quick A. J. The physiology and pathology of hemostasis. Kimpton, London: 1951 17 Rousselot L. M, Cazes B, Grossi C. E. L’inactivation par le foie des enzymesfibrinolytiques. Presse méd 71: 2677 1963;
