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Thromb Haemost 1975; 34(02): 498-503
DOI: 10.1055/s-0038-1651408
Original Article
Schattauer GmbH

Local Treatment of Recent Arterial Thromboembolic Occlusions with Brinase

D Nyman
1   Division of Coagulation and Fibrinolysis and Division of Angiology, Department of Internal Medicine, Kantonsspital, Basel, Switzerland
,
M. A da Silva
1   Division of Coagulation and Fibrinolysis and Division of Angiology, Department of Internal Medicine, Kantonsspital, Basel, Switzerland
,
L. K Widmer
1   Division of Coagulation and Fibrinolysis and Division of Angiology, Department of Internal Medicine, Kantonsspital, Basel, Switzerland
,
F Duckert
1   Division of Coagulation and Fibrinolysis and Division of Angiology, Department of Internal Medicine, Kantonsspital, Basel, Switzerland
› Author Affiliations
Further Information

Publication History

Received 07 April 1975

Accepted 09 June 1975

Publication Date:
02 July 2018 (online)

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Summary

Brinase was administered intra-arterially in 16 patients with thrombotic or embolic arterial occlusions. Angiography could be performed before and after treatment in 13 patients. Thrombolysis was obtained in 3 of 9 patients with thrombotic and in 3 of 4 patients with embolic occlusions. In 3 patients severe local side effects occurred.

 

  • References

  • 1 Amundsen E, Svendsen L, and Vefling A. 1973 A sensitive photometric method for determination of plasma inhibition towards plasmin and brinase. IVth litternational Congress on Thrombosis and Hemostasia, Vienna, p. 54 (abstracts).
    PubMedSearch in Google Scholar
  • 2 Bergqvist R. 1963; The proteolytic enzymes of Aspergillus oryzae. IV. On the inhibition of the enzymes by serum. Acta Chemica Scandinavica 17: 2239.
    CrossrefPubMedSearch in Google Scholar
  • 3 Clauss A. 1957; Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta haematologica 17: 237.
    CrossrefPubMedSearch in Google Scholar
  • 4 Cronstrand R, and Ekeström S. 1970; Bloodflow after peripheral arterial reconstruction. Scandinavian Journal of Thoracic and Cardiovascular Surgery 4: 159.
    CrossrefPubMedSearch in Google Scholar
  • 5 Duckert F. 1960; Le diagnostic des coagulopathies. Röntgen- und Labor-Praxis 15: 224.
    PubMedSearch in Google Scholar
  • 6 Fitzgerald D. E, and Frisch E. P. 1973; Relief of chronic peripheral artery obstruction by intravenous brinase. Journal of the Irish Colleges of Physicians and Surgeons 66: 3.
    PubMedSearch in Google Scholar
  • 7 Frisch E. P. 1972; Clinical experience with brinase. Journal of Clinical Pathology 25: 653.
    PubMedSearch in Google Scholar
  • 8 Frisch E. P, Lund F, Moller G, Hedin L, and Magnusson G. 1971 Animal experimental studies on the role of X-ray contrast medium in side effects observed during combined arteriography and regional thrombolysis with protease I. 6th European Conference on Microcirculation, Aalborg, p. 399, Karger, Basle.
    PubMedSearch in Google Scholar
  • 9 Godal H. C, Abildgaard IT, and Kierulf P. 1971; Ethanol gelation and fibrin-monomers in plasma. Scandinavian Journal of Haematology Suppl.13: 189.
    PubMedSearch in Google Scholar
  • 10 Kiessling H, and Svensson R. 1970; Influence of an enzyme from Aspergillus oryzae, protease I, on some components of the fibrinolytic system. Acta Chemica Scandinavica 24: 569.
    CrossrefPubMedSearch in Google Scholar
  • 11 Lund F, Hellström L, and Frisch P. 1968; Side effects observed in combined arteriography and regional thrombolytic therapy with protease. Opuscula Medica 13: 396.
    PubMedSearch in Google Scholar
  • 12 Nyman D, da Silva M. A, Widmer L. K, and Duckert F. 1974; Thrombolytische Behandlung arterieller Verschlüsse mit Brinase, einem proteolytischen Enzym aus Aspergillus. Schweizerische Medizinische Wochenschrift 104: 1865.
    PubMedSearch in Google Scholar
  • 13 Roschlau W. H. E, and Fisher A. M. 1966; Thrombolytic therapy with local perfusions of CA-7 (fibrinolytic enzyme from Aspergillus oryzae) in the dog. Angiology 17: 670.
    CrossrefPubMedSearch in Google Scholar
  • 14 Widmer L. K, and Hurlimann F. 1966; Erhöht die intraarterielle Zufuhr eines Pharmakons dessen Konzentration in den Akren ?. Zeitschrift für Kreislaufforschung 55: 410.
    PubMedSearch in Google Scholar