Thromb Haemost 1975; 34(02): 504-512
DOI: 10.1055/s-0038-1651409
Original Article
Schattauer GmbH

Effects of Experimental Coronary Thrombosis upon Regional and Systemic Plasma Chromatographic Patterns

Parimal Chowdhury
1   Department of Medicine, College of Medicine and Dentistry of New Jersey – New Jersey Medical School, Newark, New Jersey 07103
,
Christos B Moschos
1   Department of Medicine, College of Medicine and Dentistry of New Jersey – New Jersey Medical School, Newark, New Jersey 07103
› Author Affiliations
Further Information

Publication History

Received 14 October 1975

accepted 10 July 1975

Publication Date:
02 July 2018 (online)

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Summary

An evaluation of changes in the plasma chromatographic pattern was carried out in dogs with experimental coronary thrombosis. Sequential samples were taken simultaneously from the aorta and coronary sinus over a two, four and twenty-four hour period. In addition to gel-chromatography, immunodiffusion and electrophoresis were also employed to identify the protein components of the elution fractions. The results showed that there was a shift of the normal chromatographic pattern to the left from the control within two hours following thrombotic occlusion of the coronary artery and it was maintained over a twenty-four hour period. The shift to the left was presumably due to the earlier elution of the heavy molecular weight components forming as a result of the thrombotic process. The early appearance of the altered chromatographic pattern constitutes an important advantage worthy of further exploration for possible diagnostic application in the human subject.

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