Enhancement of Fibrinolysis by Venous Occlusion Results of Long-Term Thrombelastography and Activator Determination

Summary

Global fibrinolysis and activator activity were investigated in venous blood before and after occlusion. Global fibrinolysis was determinated by thrombelastography with a low speed of the paper drive (longterm thrombelastography). The fibrinolysis on the thrombelastographic curves were evaluated by the slant (a°) of the inflectional tangent at the thrombelastographic branch.

A considerable increase of global fibrinolytic activity and also of the activator activity after venous congestion was found. There was a slight correlation between the global fibrinolysis and the activator before occlusion and a strong correlation after congestion. There was, however, no accordance between the regression lines of the two correlations. Other factors of activation of fibrinolysis may be involved.

• References

• 1 Amery A, Vermylen J, Maes H, Verstraete M. Enhancing the fibrinolytic activity in human blood by occlusion of blood vessels. Thrombos. Diathes. haemorrh. (Stuttg) 07: 70 1962;
• 2 Astrup T, Müllertz S. The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem 40: 346 1952;
• 3 Ata M, Azeem P. S, Tighe J. R. The influence of venous occlusion on the fibrinolytic activity of blood. Clin. Sci 27: 357 1964;
• 4 Biggs R, Macfarlane R. G. Human blood coagulation and its disorders. Blackwell; Oxford: 1953
• 5 Clarke R. L, Orandi A, Gliffton E. E. Induction of fibrinolysis by venous obstruction. Angiology 11: 367 1960;
• 6 Gliffton E. E, Clarke R. L, Murphy J. Studies on fibrinolytic activity with venous occlusion: Treatment of thrombophlebitis. Surgery 50: 644 1961;
• 7 Feissly R, Lüdin H. Microscopie par contrastes de phases (III.-Applications a l’hématologie). Rev. Hém 03: 481 1949;
• 8 Hartert H. Blutgerinnungsstudien mit der Thrombelastographie, einem neuen Verfahren. Klin. Wschr 1948; 511.
• 9 Hartert H. Thrombelastographische Untersuchungen zur Thrombusbildung. Klin. Wschr 1949; 789.
• 10 Holemans R, Roberts H. R. Hageman factor and in vivo activation of fibrinolysis. J. Lab. clin. Med 05: 778 1964;
• 11 Holemans R, Tysinger M. F. Site of origin of increased fibrinolytic activity during venous occlusion. Proc. Soc. exp. Biol. (N. Y) 118: 488 1965;
• 12 latridis S. G, Iatridis P. G, Ferguson J. H. The role of HF (Factor XII) in the pathogenesis of the thrombolytic state induced by venous occlusion. Thrombos. Diathes. haemorrh. (Stuttg) 16: 207 1966;
• 13 Kendall M. G, Stuart A. The advanced theory of statistics. Ch. Griffin & Comp. Ltd; London: 1967
• 14 Kwaan H. C, McFadzean A. J. S. On plasma fibrinolytic activity induced by ischaemia. Clin. Sci 25: 245 1956;
• 15 Nilsson I. M, Olow B. Determination of fibrinogen and fibrinogenolytic acticity. Thrombos. Diathes. haemorrh. (Stuttg) 07: 391 1962;
• 16 Pandolfi M, Nilsson I. M, Robertson B, Isacson S. Fibrinolytic activity of human veins. Lancet II: 127 1967;
• 17 Sherry S, Lindemeyer R. L, Fletcher A. P, Alkjaersig N. Studies on enhanced fibrinolytic activity in man. J. clin. Invest 37: 931 1958;
• 18 Warren B. A. Fibrinolytic activity of vascular endothelium. Brit. med. Bull 03: 213 1964;