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Thromb Haemost 1971; 26(01): 135-144
DOI: 10.1055/s-0038-1653663
Originalarbeiten – Original Articles – Travaux Originaux
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Studies on Liver Factors which Exert an Inhibitory Effect on Platelet Aggregation

The Identification and Characterization of Platelet Aggregation Inhibitors from Rabbit Liver
W Rogowski
1   Department of Physiological Chemistry, Medical School, Bialystok, Poland
,
W GaŁasiński
1   Department of Physiological Chemistry, Medical School, Bialystok, Poland
,
E Bańkowski
1   Department of Physiological Chemistry, Medical School, Bialystok, Poland
,
W Rzeczycki
1   Department of Physiological Chemistry, Medical School, Bialystok, Poland
› Author Affiliations
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Publication Date:
28 June 2018 (online)

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Summary

The inactivating effect of rabbit liver homogenates on platelet aggregation was investigated.

The active substances were found in a nonprotein fraction of the liver homogenates. They were separated and identified as nucleotides and nucleosides. It was found that the platelet aggregation inhibiting substances obtained from the liver, inactivated the platelet aggregating factors, such as ADP, thrombin and collagen. Nucleosides and nucleotides were chromatographically separated from the liver homogenates, and their effect examined on the platelet aggregating factors. The probable mechanism of their inactivation and their pathophysiological significance are discussed.

 

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