Platelet Adhesiveness in Symptomatic Women Taking Oral Contraceptives

Summary

Platelet adhesiveness to glass was determined in several groups of women. Increases were found in women developing thrombovascular symptoms while taking combined oral contraceptives, compared to both normal women and asymptomatic users of oral contraceptives. Despite this increase, overlap of the groups did not permit discrimination between symptomatic and asymptomatic women. However, it is possible, that in concert with other coagulation changes, platelet adhesiveness to glass may prove adjunctive in defining women at increased risk of developing thrombovascular symptoms while taking oral contraceptives, and further define the mechanism of the increased risk.

• References

• 1 Bloom A. L, Evans E. P. J. clin. Path. 22: 560 1969;
• 2 Bolton C. H, Hampton J. R, Mitchell J. R. Aa. Lancet. 294: 1336 1968;
• 3 Bygdeman S, Eliasson R, Johnson S. Lancet. 290: 1301 1966;
• 4 Caspary E. A, Peberdy M. Lancet. 288: 1142 1965;
• 5 Farbiszewski R, Kurowska T. Thrombos. Diathes. haemorrh. (Stuttg). 24: 304 1970;
• 6 Ham J. M, Rose R. Amer. J. Obstet. Gynec. 105: 628 1969;
• 7 Ham J. M, Slack W. W. Brit. J. Surg. 55: 227 1968;
• 8 Hampton J. R. J. clin. Path. 23, Suppl. (Ass. Clin. Path.). 03: 75 1969;
• 9 Hume M. Surgery. 59: 110 1966;
• 10 Mayne E. E, Garville J. M. J. clin. Path. 22: 107 1969;
• 11 Moolten S. E, Vroman L, Vroman G. M. Sa. Amer. J. clin. Path. 19: 814 1949;
• 12 Nilsson I. M, Kullander S. Acta obstet, gynec. scand. 46: 286 1967;
• 13 Poller L, Priest G. M, Thomson J. M. Brit. med. J. 04: 273 1969;
• 14 Robinson R. W. Amer. J. Obstet. Gynec. 99: 163 1967;
• 15 Savitsky J. P, Werman R. Amer. J. clin. Path. 24: 161 1954;
• 16 Wright H. P. J. Path. Bact. 53: 255 1941;
• 17 Wright H. P. J. Path. Bact. 54: 461 1942;