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Thromb Haemost 1970; 23(01): 140-147
DOI: 10.1055/s-0038-1654128
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Amino Acid Transport into Human Platelets and Subsequent Incorporation into Protein

I. A Cooper   1)   2)   5)   7)
1   Clinical Research Unit, Royal Prince Alfred Hospital, and Department of Medicine, University of Sydney, Sydney, Australia
,
B. G Firkin   3)   4)   6)
1   Clinical Research Unit, Royal Prince Alfred Hospital, and Department of Medicine, University of Sydney, Sydney, Australia
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

Human platelets are known to contain various protein components. Among them are fibrinogen and other soluble proteins. The origin of such proteins has not been clear.

Studies were designed to demonstrate the ability of the platelet to incorporate amino acids and subsequently utilise these for de novo protein synthesis.

Seven different 14C labelled amino acids were used, cysteine, lysine, serine, glutamic acid, proline, valine und leucine.

Active incorporation into platelets of all these amino acids was demonstrated with some evidence for incorporation of cysteine, lysine and serine into the fibrinogen and soluble protein.

1) Johnson and Johnson Research Fellow 1966–1967 Royal Australasian College of Plrysicians.


2) Honorary Physician.


3) Associate Professor in Medicine (Biochemistry) and Director of Clinical Research.


4) Supported by a Life Assurance Medical Fund of Australia and New Zealand.


5) Present Adress: Clinical Haamatologist, Cancer Institute, 278 William Street, Melbourne, Victoria 3000, Australia.


6) Present Adress: Professor of Medicine, Monash University Medical School, Alfred Hospital, Commercial Road, Prahran, Victoria.


7) Requests for reprints should be sent to I. A. Cooper.