Simultaneous Development of Platelet Factor 4 Activity and Release of ¹⁴C-Serotonin^[*]

Summary

Development of platelet factor 4 activity induced under various conditions by ADP, epinephrine, or connective tissue correlated well with release of ¹⁴C-serotonin measured simultaneously. In many ways connective tissue behaved differently from ADP and epinephrine, e.g., it caused PF-4 activity and 140-serotonin release in unstirred platelet-rich plasma and was effective in platelet-rich plasma from a thrombasthenic patient whereas ADP and epinephrine were not.

^* Work partially supported by U.S. Public Health Service Grant No. HE-12859, National Heart and Lung Institute. Contribution No. 201 from the Blood Research Laboratories, American National Red Cross.

^** Please send reprint requests to Dr. Zucker. Present affiliation, Department of Pathology.

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