Platelet Aggregation and Platelet Factor 3 Activity in Myeloproliferative Disorders

Y Tangün

doi:10.1055/s-0038-1654299

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1971; 25(02): 241-251
DOI: 10.1055/s-0038-1654299

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Platelet Aggregation and Platelet Factor 3 Activity in Myeloproliferative Disorders

Y Tangün M. D.*

¹Department of Hematology, First Internal Clinic of Istanbul Medical School, Çapa, Istanbul (Turkey)

› Author Affiliations

Abstract

Summary

33 patients with myeloproliferative disorder were studied and in 28 (84%) various anomalies of platelet function were observed. Single, or more commonly, multiple platelet aggregation defects and impaired release of platelet ADP and platelet factor 3 activity were the chief anomalies noted, whether thrombocytosis was present or not. The effect of myelosuppressive therapy upon the defects demonstrated varied from patient to patient, and from one anomaly to another. Reducing the high platelet count to normal levels does not seem to be sufficient to eradicate qualitative platelet defects.

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References

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