Platelet Aggregation and Platelet Factor 3 Activity in Myeloproliferative Disorders

Summary

33 patients with myeloproliferative disorder were studied and in 28 (84%) various anomalies of platelet function were observed. Single, or more commonly, multiple platelet aggregation defects and impaired release of platelet ADP and platelet factor 3 activity were the chief anomalies noted, whether thrombocytosis was present or not. The effect of myelosuppressive therapy upon the defects demonstrated varied from patient to patient, and from one anomaly to another. Reducing the high platelet count to normal levels does not seem to be sufficient to eradicate qualitative platelet defects.

• References

• 1 Abraham J. P, Ulutin O. N, Johnson S. A, Caldwell M. J. A study of the defects in the blood coagulation mechanism in polycythemia vera. Amer. J. clin. Path 36: 7 1961;
• 2 Borchgrevink C. F. A method, for measuring platelet adhesiveness in vivo. Acta med. scand 168: 157 1960;
• 3 Brecher G, Gronkite E. P. Morphology and enumeration of human blood platelets. J. app. Physiol 03: 365 1950;
• 4 Gaen J, Sinakos Z, Sultan Y, Vainer H, Bernard J. Les troubles du fonctionnement des plaquettes dans les leucémies myéloides chroniques. Nouv. Rev. franç. Hémat 06: 719 1966;
• 5 Gaen J. P, Sultan Y, Delobel J. Les thrombopathies acquises. Nouv. Rev. franç. Hémat 09: 553 1969;
• 6 Gaen J, Sultan Y, Dreyfus B. Etude des fonctions plaquettaires dans 7 cas d’anémie réfractaire. Nouv. Rev. franç. Hémat 09: 123 1969;
• 7 Gronberg S, Nilsson I. M, Gydell K. Haemorrhagic thrombocythaemia due to defect of platelet adhesiveness. Scand. J. Haemat 02: 208 1965;
• 8 Didisheim P, Bunting D. Abnormal platelet function in myelofibrosis. Amer. J. clin. Path 45: 566 1966;
• 9 Hardisty R. M, Wolff H. H. Haemorrhagic thrombocythaemia: a clinical and laboratory study. Brit. J. Haemat 01: 390 1955;
• 10 Horowitz H. I, Papayoanou M. F. Activation of platelet factor 3 by adenosine 5’diphosphate. Thrombos. Diathes. haemorrh. (Stuttg.) 19: 18 1968;
• 11 Inceman S, Tangün Y. Platelet factor 3 availability in Glanzmann's disease. Israel J. med. Sci 05: 1259 1969;
• 12 Inceman S, Tangün Y. A simple test for the evaluation of platelet coagulant activity. J. Lab. clin. Med 74: 174 1969;
• 13 Jellett L. B, Bonnin J. A. Platelet thromboplastic function in polycythaemia and thrombocythaemia. Aust. Ann. Med 15: 51 1966;
• 14 Karaca M, Stefanini M, Mele R. Studies on platelets. XXV. Chemical analysis of platelets from patients with congenital and acquired thrombocytopathy, with special reference to phospholipids. J. Lab. clin. Med 67: 229 1966;
• 15 Marcus A. J, Zucker M. B. The Physiology of Blood Platelets. Grune and. Stratton; New York: 1965
• 16 McClure P. D, Ingram G. I. C, Stacey R. S, Glass U. H, Matchett M. O. Platelet function tests in thrombocythaemia and thrombocytosis. Brit. J. Haemat 12: 478 1966;
• 17 Salzman E. W. Measurement of platelet adhesiveness. A simple in vitro technique demonstrating an abnormality in von Willebrand’s disease. J. Lab. clin. Med 62: 724 1963;
• 18 Sinakos Z, Caen J. Une technique simple, quantitative de mesure de l’agrégation plaquettaire. Rev. franç. Étud. clin. biol 11: 539 1966;
• 19 Spaet T. H, Bauer S, Melamed S. Hemorrhagic thrombocythemia. A blood coagulation disorder. Arch. intern. Med 98: 377 1956;
• 20 Spaet T. H, Cintron J. Studies on platelet factor-3 availability. Brit. J. Haemat 11: 269 1965;
• 21 Spaet T. H, LejnieJcs I, Gaynor E, Goldstein M. L. Defective platelets in essential thrombocythemia. Arch. intern. Med 124: 135 1969;
• 22 Stefanini M, Damesinek W. The Hemorrhagic Disorders. A Clinical and Therapeutic Approach. 2. ed. Grune and Stratton; New York: 1962
• 23 Ulutin O. N. The qualitative platelet diseases. In: Blood Platelets. Johnson S. A, Monto R. W, Rebuck J. W, Horn Jr. R. C. 553 Little, Brown and Co; Boston: 1961
• 24 Weiss H. J. Platelet aggregation, adhesion and adenosine diphosphate release in thrombopathia (platelet factor 3 deficiency). A comparison with Glanzmann’s thrombasthenia and von Willebrand’s disease. Amer. J. Med 43: 570 1967;
• 25 Weiss H. J, Eichelberger Jr J. W. Secondary thrombocytopathia. Platelet factor 3 in various disease states. Arch. intern. Med 112: 827 1963;