Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 1960; 4(02): 283-288
DOI: 10.1055/s-0038-1654507
DOI: 10.1055/s-0038-1654507
Originalarbeiten — Original Articles — Travaux Originaux
Thromboplastic Activity of Split Products of Phosphatidyl Ethanolamine
Further Information
Publication History
Publication Date:
26 July 2018 (online)
Summary
Pure synthetic L-α-(dioleoyl) PE is inactive as a platelet substitute in the thromboplastin generation test, even when in a stable suspension. Under humid conditions it is partly hydrolyzed. Among the split products lyso PE and phosphoryl ethanolamine were identified. The resulting mixture has thromboplastin generating activity. This thromboplastin is formed slowly, but it is stable over longer periods of time than thromboplastins formed from PS + PC or PS + PE mixtures, which are rapidly generated and lose activity faster.
-
References
- (1) Therriault D, Nicols Th, Jensen H. Purification and identification of brain phospholipids associated with thromboplastic activity. J. biol. Chem. 233: 1061 1958;
- (2) Slotta K. H. Thromboplastin. I. The phospholipid mojety of thromboplastin. Proc. Soc. exp. Biol. Med.. In press.
- (3) Biggs R, Douglas A. S, McFarlane R. G. The formation of thromboplastin in human blood. J. Physiol. 119: 89 1953;
- (4) Poole J. C. F, Robinson S. D. Comparison of effect of certain phosphatides and of chylomicra on plasma coagulation in presence of Russell’s viper venom. Quart. J. exp. Physiol. 41: 31 1956;
- 4a Poole J. C. F, Robinson S. D. Further observations on effect of ethanolamine phosphatide on plasma coagulation. Quart. J. exp. Physiol. 41: 295 1956;
- (5) O’Brien J. R. Effect of a meal of eggs and different fats on blood coagulability. Lancet 271: 232 1956;
- 5a O’Brien J. R. The similarity of action of phosphatidyl ethanolamine and platelets in blood coagulation. J. clin. Path. 9: 47 1956;
- (6) Rouser G, White S. G, Schloredt D. Phospholipid structure and thromboplastic activity. Biochim. biophys. Acta 28 (71) 81 1958;
- (7) Kuhn R, Klesse P. Zur chemischen Konstitution des Lipoids der Thrombokinase. Naturwissenschaften 44: 352 1957;
- (8) Bidwell E, Biggs R. Development of platelet-like activity on storage of crude egg phospholipoid. J. Physiol. 138: 37P 1957;
- (9) Deutsch E, Kain W. Über den Einfluß von Lipoiden und Lipoidlösungsmitteln auf die Blutgerinnung. 7. Internationaler Kongreß f. Hämatologie. Rom: 1958