The Inhibitory Action of Adsorbed Undiluted Plasma (normal or pathological) on the Thromboplastin Generation Test

Summary

In considering errors made during the search for a weak inhibitor of thromboplastin generation in a patient suffering from multiple myeloma, the authors recall the inhibitory action of adsorbed undiluted plasma added to a thromboplastin generation test. They stress the non-specificity of this inhibitory action which is common to all adsorbed plasma (normal, myelomatous or hemophilic) added undiluted to the test of Biggs and Douglas.

^* With the technical assistance of Miss E. Ribs.

• References

• (1) Biggs R, Douglas A. S. The thromboplastin generation test. J. clin. Path. 6: 23 1953;
• (2) Biggs R, Macfarlane R. G. Human blood coagulation and its disorders. Second edition. 416-417 Blackwell Scientific Publications; Oxford: 1957
• (3) Biggs R. The inhibitory effect of haemophilic plasma. Brit. J. Haemat. 4: 192-200 1958;
• (4) Nour-Eldin F, Wilkinson J. F. Bridge anticoagulant: a hitherto unrecognized blood clotting inhibitor in haemophilic and Christmas disease plasma. A simple method for its demonstration. Brit. J. Haemat. 4: 38-50 1958;
• (5) Nour-Eldin F, Wilkinson J. F. The inhibitory effect of haemophilic plasma. Brit. J. Haemat. 4: 292-301 1958;