Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Thromb Haemost 1961; 6(03): 485-491
DOI: 10.1055/s-0038-1654579
DOI: 10.1055/s-0038-1654579
Originalarbeiten — Original Articles — Travaux Originaux
The Influence of Fibrin Stabilizing Factor on the Growth of Fibroblats in vitro and Wound Healing
Further Information
Publication History
Publication Date:
12 July 2018 (online)
Summary
Congenital deficiency of Fibrin Stabilizing Factor (FSF) is the cause of both pathological haemostasis and poor wound healing. Experiments with fibroblast cultures were carried out to characterize the latter. Growth of the cultures in the patient’s plasma was quantitatively and qualitatively inferior as compared with the growth in normal control plasma, which contained FSF. Only by addition of normal plasma and purified FSF the poor cell growth was corrected. The necessity of fibrin present in the first stage of wound healing and possible modes of action of FSF in haemostasis and wound healing are discussed.
-
References
- (1) Astrup T. Blutgerinnung, Fibrinolyse und Wundheilung. Medizinische. 1959. 1972
- (2) Beck E, Duckert F, Ernst M. Fibrinstabilisierender Faktor (FSF) und Wundheilung. Proc. VIII. Kongr. Europ. Ges. Haematol.. Wien: 1961. in press
- (3) Duckert F, Jung E, Shmerling D. H. A hitherto undescribed congenital haemorrhagic diathesis probably due to Fibrin Stabilizing Factor deficiency. Thromb. Diath. haem. 5: 179 1960;
- (4) Edwards D. C, Dunphy J. E. Wound healing. New Engl. J. Med. 259: 224 1958;
- (5) Florey H. Healing. Chapter 18 in General Pathology. 2nd. Ed.. Lloyd-Luke Ltd.; London: 1958
- (6) Gillman T, Penn J. Studies on repair of cutaneous wounds. Med. Proc. 2: 121 1956;
- (7) Laki K, Lorand L. On the solubility of fibrin clots. Science 108: 280 1948;
- (8) Loewy A. G, Edsall J. T. Studies on the formation of ureainsoluble fibrin. J. biol. Chem. 211: 829 1954;
- (9) Lorand L. Proc. Intern. Congr. Soc. Haematol. Cambridge England: 1950. 407 1951
- (10) Lorand L, Dickenman R. C. Assay method for the “Fibrin-Stabilizing Factor”. Proc. Soc. exp. Biol. (N. Y.) 89: 45 1955;
- (11) Lorand L, Jacobsen A. Studies on the polymerization of fibrin. The role of the globulin: Fibrin-Stabilizing Factor. J. biol. Chem. 230: 421 1958;
- (12) Macfarlane R. G. A boy with no fibrinogen. Lancet 1: 309 1938;
- (13) Shmerling D. H, Jung E, Duckert F. Eine neue familiäre Koagulopathie infolge Mangels an fibrinstabilisierendem Faktor. Helv. paediat. Acta 15: 5 471 1960;
- (14) Weiss P. Erzwingung elementarer Strukturverschiedenheiten am in vitro wachsenden Gewebe. Die Wirkung mechanischer Spannung auf Richtung und Intensität des Gewebs-wachstums und ihre Analyse. Arch. Entwickl.-Mech. org. 116: 438 1929;