Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1963; 10(01): 151-163DOI: 10.1055/s-0038-1654771 Originalarbeiten — Original Article — Travaux Originaux Schattauer GmbH Inactivation of Antiplasmin and Complement C1 in Human Plasma Rendered Fibrinolytic by Synthetic Organic Compounds[*] Kurt N von Kaulla with the technical assistance of John Eisele and Marlow Ens 1 Department of Medicine, University of Colorado School of Medicine, Denver/Colorado › Author Affiliations Recommend Article Abstract Buy Article Summary Certain synthetic organic compounds induce upon dissolution marked fibrinolytic activity in human plasma, reduce the antiplasmin titer of human or bovine serum and destroy the complement C1 of human plasma. Generation of fibrinolytic activity and reduction of antiplasmin are concentration-depending time reactions. Destruction of complement C1 occurs almost instantaneously. Minor molecular modifications abolish all three activities of the compounds. Full Text References References 1 von Kaulla K. N. Chemical structure and fibrinolysis induction in vitro. Studies with 126 compounds. Thrombos. Diathes haemorrh. (Stuttg.) 07: 404 1962; 2 von Kaulla K. N. The chemistry of thrombolysis: Human fibrinolytic enzymes. C. C. Thomas Publisher; Springfield: 1963: 333. 3 Michaelis L. Der Azetatpuffer. Biochem. 2. 234: 139 1931; 4 Mayer M. M. Hemolytic assay of complement. in: Kabat E. A, Mayer M. M. Experimental immunochemistry.. C. C. Thomas; Springfield: 2nd Edition. 1961: 133. 5 von Kaulla K. N, Smith R. L. Urea derivatives as fibrinolysis promoting agents. Proc. Soc. exp. Biol. 106: 530 1961;
