Summary and Conclusions
Moderate intravascular hemolysis was produced in rats by intraperitoneal injections
of hemolysate prepared from rats.
1. An accelerated clotting time of recalcified plasma and an increased platelet adhesiveness
were observed during the first ten hours after the injection.
2. An increase of the fibrinogen and proaccelerin level of plasma were observed 24—48
hours after the injection.
3. No increased antifibrinolytic activity was found.
4. No significant increase in the incidence of thrombosis was observed during the
first 24 hours after the injection whereas a high incidence of thrombosis indicating
a hyperthrombotic state was observed 24—48 hours after the injection, at a time when
the hemoglobinemia had disappeared. In a group of animals given a second injection
of hemolysate 24 hours after the first injection a hyperthrombotic state was still
present 25—48 hours after the first injection with an incidence of thrombosis equal
to that noted 24—48 hours after a single injecion only.
5. The present study may indicate that the hyperthrombotic state present during moderate
intravascular hemolysis is associated with an increased formation of fibrinogen, factor
V (proaccelerin) and probably factor VIII (AHG).
