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Thromb Haemost 1964; 11(01): 099-107
DOI: 10.1055/s-0038-1654810
Originalarbeiten — Original Articles — Travaux Originaux
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Lysis of the Experimental Radioactive Pulmonary Embolus Induced by Streptokinase and SK-Activated Plasmin*

Michael Hume   **)
1   Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
› Author AffiliationsThe work was supported in part by research grants H-5140 from the U. S. Public Health Service and 60 G 38 from the American Heart Assoc.
The author acknowledges gratefully the invaluable assistance rendered by Susan H. Jones, A, Negri, Evelyn O. Jackson, Barbara Gillette, and Loretta Hemingson.
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Publication Date:
22 June 2018 (online)

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Summary

The experimental radioactive pulmonary embolus, made from human blood, introduced into the dog, was used to demonstrate efficacy of several streptokinase and SK-activated plasmin preparations. Demonstrable lysis was observed with each of these agents, but varied with dose administered, and with other factors still obscure. This experimental method presents several advantages for in vivo evaluation and comparison of thrombolytic agents, including the following: (1) The animal is large enough to permit multiple blood samples to be taken; (2) The test material is human and may be modified if desired; (3) Continuous observation is possible ; (4) Spontaneous lysis is differentiated from induced lysis by waiting during a control period for a steady state to be reached; (5) Several criteria of successful lysis confirm each other; (6) Residual embolus can be located at necropsy; (7) More than one dose or one agent can be given in a single experiment.

**) Assistant Professor of Surgery, Yale University School of Medicine. The author is a Markle Scholar in Academic Medicine.


 

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