Investigations on Adenosine Diphosphate (ADP) Induced Platelet Adhesiveness in Vitro* Part II. Studies on the Mechanism

B. A Skålhegg; A. J Hellem; A. E Ödegaard

doi:10.1055/s-0038-1654831

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1964; 11(02): 305-316
DOI: 10.1055/s-0038-1654831

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Investigations on Adenosine Diphosphate (ADP) Induced Platelet Adhesiveness in Vitro* Part II. Studies on the Mechanism

Authors

B. A Skålhegg

¹Institute for Thrombosis Research, University Hospital, Rikshospitalet, Oslo, Norway. Head: P. A. Owren, M. D
A. J Hellem

¹Institute for Thrombosis Research, University Hospital, Rikshospitalet, Oslo, Norway. Head: P. A. Owren, M. D
A. E Ödegaard

¹Institute for Thrombosis Research, University Hospital, Rikshospitalet, Oslo, Norway. Head: P. A. Owren, M. D

Abstract

Summary

An attempt to clarify the ADP platelet reaction has been done by investigating the effect of substances which inhibit the reaction in vitro. The inhibitors used may be divided into two groups. Monoiodo acetic acid, molecular iodine, para-chloro mercuribenzoic acid and potassium ferricyanid lead to noncompetitive inhibition. Substances containing free -SH groups and adenine conjugates show competitive inhibition.

The primary bleeding time is prolonged when wounds are flushed with solutions of these compounds.

It is shown that adenosine tetraphosphate aggregates platelets in the same manner as ADP.

Based upon these observations an attempt is made to explain some of the steps involved in the ADP platelet reaction.

Full Text

References

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