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Thromb Haemost 1965; 14(01/02): 052-064
DOI: 10.1055/s-0038-1654853
Originalarbeiten — Original Articles — Travaux Originaux
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The Fibrinotic Index and Evidence for a Balanced Regulation of Coagulation Activities*

G. F Grannis
1   The Cardeza Foundation for Hematological Research Jefferson Medical College, Philadelphia, Pennsylvania
,
L. A Kazal
1   The Cardeza Foundation for Hematological Research Jefferson Medical College, Philadelphia, Pennsylvania
› Author AffiliationsSupported in part by NIH Grant HE 3544 from the National Heart Institute, U.S.P.H.S.
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Publication Date:
24 July 2018 (online)

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Summary

The fibrinogen, plasma antithrombin, and thrombin activity curves of twenty-four normal individuals were determined under carefully controlled conditions of analysis. From these determinations plasma prothrombin and thromboplastic activities were calculated. These activities were defined in kinetic terminology and a theoretical rate of fibrination in plasma was calculated and used as a basis for comparing plasmas. Compensatory relationships were found among the various activities. Thus, low values of thromboplastic activity were associated with increased concentrations of prothrombin and fibrinogen; the effect of the latter activities in increasing the potential of plasma for fibrination was moderated by an increase in antithrombin activity.

The fibrin-forming potential of each plasma was calculated relative to the mean value for all plasmas, to furnish a fibrinotic index. The latter was relatively constant in spite of wide variations in discrete activities, indicating that a physiological balance is maintained among those coagulation factors responsible for fibrination.

 

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