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Thromb Haemost 1965; 14(01/02): 202-208
DOI: 10.1055/s-0038-1654864
Originalarbeiten — Original Articles — Travaux Originaux
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Platelet Aggregation in Waldenstrom’s Macroglöbulinaemia*

M. C Rozenberg
1   Clinical Research Unit, Royal Prince Alfred Hospital, and the Department of Medicine, University of Sydney, New South Wales, Australia
,
L Dintenfass
1   Clinical Research Unit, Royal Prince Alfred Hospital, and the Department of Medicine, University of Sydney, New South Wales, Australia
› Author AffiliationsSupported by the National Heart Foundation of Australia.
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Publication History

Publication Date:
24 July 2018 (online)

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Summary

The morphology of coagula obtained in the cone in cone viscometer is studied in two cases of Waldenstrom’s macroglobulinaemia. Whereas the structures obtained in normal individuals have the features of in vivo thrombosis, the platelet masses usually obtained are not present in the two patients studied. It is postulated that disturbance of platelet aggregation as demonstrated may account for the bleeding diathesis in some cases of Waldenstrom’s macroglobulinaemia.

 

  • References

  • 1 Waldenstrom J. Incipient myelomatosis or essential hyperglobulinaemia with fibrinogenopenia-anew syndrome ? Acta. med. scand. 117: 216 1944;
    PubMedGoogle Scholar
  • 2 Pachter M. R, Johnson S. A, Neblett T. R, Truant J. P. Bleeding, platelets and macroglobulinaemia. Amer. J. clin. Path. 31: 467 1959;
    PubMedGoogle Scholar
  • 3 Izarn P. Les anomalies dn temps de saignement an cours des dysglobulinemies. Nonv. Rev. franc. Hémat. 03: 340 1963;
    PubMedGoogle Scholar
  • 4 Perry S. Coagulation factors in patients with plasma protein disorders. J. Lab. clin. Med. 61: 411 1963;
    PubMedGoogle Scholar
  • 5 Rozenberg M. C, Dintenfass L. Thrombus formation in vitro: a rheological and morphological study. Aust. J. exp. Biol. med. Sci. 42: 109 1964;
    PubMedGoogle Scholar
  • 6 Dintenfass L, Rozenberg M. C. The effect of velocity gradient on the coagulation of blood. J. Atheroscler. Res. (In press.)
    PubMedGoogle Scholar
  • 7 Dintenfass L. Thixotropy of blood and proneness to thrombus formation. Circulât. Res. 11: 233 1962;
    PubMedGoogle Scholar
  • 8 Dintenfass L. Viscosity and clotting of blood in venous thrombosis and coronary occlusion. Circulât. Res. 14: 1 1964;
    PubMedGoogle Scholar
  • 9 Proctor R. B, Rapjpaport S. I. The partial thromboplastin time with kaolin. Amer. J. clin. Path. 36: 212 1961;
    PubMedGoogle Scholar
  • 10 Biggs R, MacFarlane R. G. Human blood coagulation. 3rd. ed. Blackwell scientific publications; 1962
    Google Scholar
  • 11 Butler E. A, Flynn F. V, Hanis H, Robson E. B. The laboratory diagnosis of macroglobulinaemia. Lancet II: 289 1961;
    PubMedGoogle Scholar
  • 12 Roskam J. Erreurs anciennes et perspectives neuvelles dans l’etude de l’adhesion, de l’aggregation, et de la metamorphose visqueuse des plaquettes, facteurs d’hemostase. Thromb. Diathes. haemorrh. (Stuttg) 10: 253 1963;
    PubMedGoogle Scholar
  • 13 Bizzozero J. Über einen neuen Formbestandteil des Blutes und dessen Rolle bei der Thrombose und der Blutgerinnung. Virchows Arch. path. Anat. 90: 261 1882;
    CrossrefPubMedGoogle Scholar
  • 14 Braunsteiner H, Falkner R, Neumayer A, Pakesch F. Makromoleculare Kryoglobulinaemie. Klin. Wschr. 32: 722 1954;
    CrossrefPubMedGoogle Scholar
  • 15 Borchgrevink ChF. Platelet adhesion in vivo in patients with bleeding disorders. Acta, med. scand. 170: 245 1965;
    PubMedGoogle Scholar
  • 16 Jorgensen L, Borchgrevink ChF. The haemostatic mechanism in patients with haemorrhagic diseases. A histological study of wounds made for primary and secondary bleeding time tests. Acta. path, microbiol. scand. 60: 55 1964;
    CrossrefPubMedGoogle Scholar