Studies on Hypercoagulable State

G Izak; K Galewski; Z Eyal

doi:10.1055/s-0038-1655064

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1967; 18(03/04): 544-551
DOI: 10.1055/s-0038-1655064

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Studies on Hypercoagulable State

II. The Application of ¹³¹I-Labelled Fibrinogen for the Estimation of Intravascular Coagulation in Human Subjects

Authors

G Izak M. D.

¹Department of Medicine B, the Hematology Research Laboratory and the Department of Surgery A, of the Hebrew University-Hadassah Medical School and the Hadassah University Hospital, Jerusalem (Israel)
K Galewski

¹Department of Medicine B, the Hematology Research Laboratory and the Department of Surgery A, of the Hebrew University-Hadassah Medical School and the Hadassah University Hospital, Jerusalem (Israel)
Z Eyal M. D.

¹Department of Medicine B, the Hematology Research Laboratory and the Department of Surgery A, of the Hebrew University-Hadassah Medical School and the Hadassah University Hospital, Jerusalem (Israel)

Abstract

Summary

The rate of disappearance of ¹³¹I-labelled, purified fibrinogen was estimated in 43 human subjects simultaneously with repeated determinations of various other constituents of the coagulation and fibrinolytic systems.

A marked shortening of theT/2 of ¹³¹I-labelled fibrinogen was observed in patients with thromboembolic disease, as well as in some patients following extensive surgical procedures, in the absence of clinical signs of occlusive vascular lesions at the time of the study. In some of the latter patients thromboembolic episodes developed subsequently.

The application of the procedures described here in the diagnosis of the so-called hypercoagulable state is discussed.

Full Text

References

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