Platelet Changes after Adrenaline Infusions with and without Adrenaline Blockers

P. D McClure; G. I. C Ingram; R Vaughan Jones

doi:10.1055/s-0038-1656292

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1965; 13(01): 136-139
DOI: 10.1055/s-0038-1656292

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Platelet Changes after Adrenaline Infusions with and without Adrenaline Blockers

P. D McClure^*

¹Department of Haematology, Louis Jenner Laboratories, St. Thomas’s Hospital and Medical School, London, S.E. I.

,

G. I. C Ingram

¹Department of Haematology, Louis Jenner Laboratories, St. Thomas’s Hospital and Medical School, London, S.E. I.

,

R Vaughan Jones

¹Department of Haematology, Louis Jenner Laboratories, St. Thomas’s Hospital and Medical School, London, S.E. I.

› Author Affiliations

Abstract

Summary

Adrenaline infusions into young, healthy, male subjects produced a rise in both platelet counts and platelet adhesiveness. Pronethalol, a ß-blocker of adrenaline, blocked these changes. Phentolamine, an α-blocker, produced a fall in platelet count which interfered with the interpretation of its blocking effect. The results suggested however, that Phentolamine did not prevent the increase in platelet adhesiveness produced by adrenaline.

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References

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