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Semin intervent Radiol 2018; 35(04): 215-220
DOI: 10.1055/s-0038-1669467
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Bone and Soft-Tissue Biopsies: What You Need to Know

Dimitrios K. Filippiadis
1   2nd Radiology Department, “ATTIKON” University General Hospital, National and Kapodistrian University of Athens, Athens, Greece
,
George Charalampopoulos
1   2nd Radiology Department, “ATTIKON” University General Hospital, National and Kapodistrian University of Athens, Athens, Greece
,
Argyro Mazioti
1   2nd Radiology Department, “ATTIKON” University General Hospital, National and Kapodistrian University of Athens, Athens, Greece
,
Kalliopi Keramida
2   Heart Failure Unit, “ATTIKON” University General Hospital, National and Kapodistrian University of Athens, Greece
,
Alexis Kelekis
1   2nd Radiology Department, “ATTIKON” University General Hospital, National and Kapodistrian University of Athens, Athens, Greece
› Author Affiliations
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Publication History

Publication Date:
05 November 2018 (online)

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Abstract

Percutaneous, image-guided musculoskeletal biopsy, due to its minimal invasive nature, when compared with open surgical biopsy, is a safe and effective technique which is widely used in many institutions as the primary method to acquire tissue and bone samples. Indications include histopathologic and molecular assessment of a musculoskeletal lesion, exclusion of malignancy in a bone/vertebral fracture, examination of bone marrow, and infection investigation. Preprocedural workup should include both imaging (for lesion assessment and staging) and laboratory (including coagulation tests and platelet count) studies. In selected cases, antibiotic prophylaxis should be administered before the biopsy. Core needle biopsy of musculoskeletal lesions has a diagnostic accuracy that ranges from 66 to 98% with higher diagnostic yield for lytic, large-size, malignant lesions and when multiple and long specimens are obtained. Reported complication rates range between 0 and 10% and usually do not exceed 5%, with a suggested threshold of 2%. The purpose of this review article is to illustrate the technical aspects, the indications, and the methodology of percutaneous image-guided bone biopsy that will assist the interventional radiologist to perform these minimal invasive techniques.

Keywords

musculoskeletal lesion - percutaneous biopsy - Imaging guidance - interventional radiology

Note

The reader is referred to a prior article in Seminars in Interventional Radiology that also covers musculoskeletal biopsies.[12]


 

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