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Am J Perinatol 2019; 36(06): 641-646
DOI: 10.1055/s-0038-1673397
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A Mystery of Patent Ductus Arteriosus and Serum Osmolality in Preterm Infants

Ufuk Cakir
1   Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
,
Cuneyt Tayman
1   Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey
› Author Affiliations Funding None.
Further Information

Publication History

23 July 2018

29 August 2018

Publication Date:
06 October 2018 (online)

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Abstract

Objective Patent ductus arteriosus (PDA) is an important clinical problem associated with mortality and serious morbidities. It is thought that serum osmolality may affect ductal patency. We aimed to investigate the importance of serum osmolality related to ductal patency in preterm infants.

Study Design Our study was conducted between January 2013 and December 2017. Premature infants with birth weight <1,500 g and gestational age <32 weeks were included in the study. Serum osmolality was compared between infants with hemodynamically significant PDA (hsPDA) and non-hsPDA.

Results During the study period, 799 patients were evaluated. Mean serum osmolality levels were higher in the “hsPDA” group (297 ± 10.9 vs. 292 ± 8.3 mOsm/L) (p = 0.001). The area under the curve for osmolality was 0.582 (p = 0.0006, 95% confidence interval: 0.541–0.622) at the time of diagnosis for predicting hsPDA, with a cutoff value for osmolality of 300 mOsm/L.

Conclusion Serum osmolality may be recognized as an important contributing factor for ductal patency especially among extremely preterm infants who are most likely to have hsPDA in the early days of life.

Keywords

hemodynamically significant patent ductus arteriosus - premature - serum osmolality - very low birth weight
 

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