Sepsis Biomarkers

Hector R. Wong

doi:10.1055/s-0038-1677537

Journal of Pediatric Intensive Care, Table of Contents

J Pediatr Intensive Care 2019; 08(01): 011-016
DOI: 10.1055/s-0038-1677537

Review Article

Georg Thieme Verlag KG Stuttgart · New York

Sepsis Biomarkers

Hector R. Wong

¹Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Research Foundation, Cincinnati, Ohio, United States

²Department of Pediatrics, University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States

› Author Affiliations

Abstract

Sepsis-related biomarkers have a variety of potential applications. The most well-known application is to differentiate patients with signs of systemic inflammation caused by infection, from those with systemic inflammation due to a non-infectious cause. This application is important for timely and judicious prescription of antibiotics. Apart from diagnostic applications, biomarkers can also be used to identify patients with sepsis who are at risk for poor outcome and to subgroup patients with sepsis based on biological commonalities. The latter two applications embody the concepts of prognostic and predictive enrichment, which are fundamental to precision medicine. This review will elaborate on these concepts, provide relevant examples, and discuss important considerations in the process of biomarkers discovery and development.

Keywords

biomarkers - sepsis - diagnostic

Full Text

References

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