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J Pediatr Infect Dis 2019; 14(04): 155-160
DOI: 10.1055/s-0039-1683388
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Community-Acquired Pneumonia Due to Virus and Mycoplasma pneumoniae Infection in Children Younger than 5 Years

Huiming Sun   *
1   Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China
,
Wenqing Zhu   *
2   Department of Pharmacy, Children's Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China
,
Zhengrong Chen
1   Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China
,
Wei Ji
1   Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China
,
Chuangli Hao
1   Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China
,
Zhang Xinxing
1   Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China
,
Gu Wenjing
1   Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China
,
Yuqing Wang
1   Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China
› Author Affiliations
Further Information

Publication History

26 July 2018

01 February 2019

Publication Date:
07 March 2019 (online)

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Abstract

The purpose of this study was to determine the clinical features of viral pathogens and Mycoplasma pneumoniae in children hospitalized with community-acquired pneumonia (CAP). M. pneumoniae infection was diagnosed by both serology and polymerase chain reaction (PCR). Respiratory viruses were detected by direct immunofluorescence or PCR. Medical records of children younger than 5 years diagnosed with 5-day-old CAP were reviewed. Viral pathogens and/or M. pneumoniae were detected in 388 (15.59%) children in the following three groups: viral monoinfection (n = 321), M. pneumoniae with viral coinfection (n = 17), and M. pneumoniae monoinfection (n = 50). M. pneumoniae monoinfection was characterized by older age, fever, higher neutrophil count, and chest X-ray showing lobar consolidation. Wheezing was more common in children with viral infections. Elevated alanine aminotransferase and aspartate aminotransferase were commonly seen in children with Mycoplasma infections. The median symptom duration in children with viral coinfection was shorter than in the other two groups (both p < 0.05). M. pneumoniae and respiratory viruses are important etiologic agents for CAP in children younger than 5 years, with characteristic clinical features. M. pneumoniae and viral coinfection are associated with shorter duration of symptoms before admission.

Keywords

coinfection - Mycoplasma pneumoniae - virus

Ethical Approval

All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendment or comparable ethical standards.


Informed Consent

Informed consent was obtained from all individual participants included in the study.


* Huiming Sun and Wenqing Zhu contributed equally to this study.