The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort Study

Ahmed M. Maged; Amira Y. Shoab; Eman A. Hussein; Ahmed H. Alsawaf; Doaa S. Mahmoud; Ameer A. AbdAllah; Sherif Dahab; Mohamed Darwish; Yahia Z. Ali; Haitham Badran

doi:10.1055/s-0039-1683438

American Journal of Perinatology, Table of Contents

Am J Perinatol 2020; 37(05): 491-496
DOI: 10.1055/s-0039-1683438

Original Article

The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort Study

Ahmed M. Maged

¹Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt

,

Amira Y. Shoab

¹Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt

,

Eman A. Hussein

¹Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt

,

Ahmed H. Alsawaf

¹Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt

,

Doaa S. Mahmoud

¹Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt

,

Ameer A. AbdAllah

²Department of Obstetrics and Gynecology, Minia University, Minia, Egypt

,

Sherif Dahab

¹Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt

,

Mohamed Darwish

³Department of Gynecology and Obstetrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

,

Yahia Z. Ali

⁴Department of Gynecology and Obstetrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt

,

Haitham Badran

⁴Department of Gynecology and Obstetrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt

› Author Affiliations

Abstract

Objective This study aimed to evaluate the effect of vaginal progesterone (P) administration during the second and third trimesters of pregnancy on Doppler velocimetry of uterine, umbilical, and middle cerebral vessels.

Study Design A prospective cohort study conducted on 80 women at risk for preterm labor. Uterine artery, umbilical artery, and middle cerebral artery (MCA) Doppler indices were measured before and after 1 week of administration of 200 mg twice daily vaginal P. The primary outcome parameter was the change of MCA pulsatility index (PI) after P administration. Secondary outcomes included changes in uterine artery and umbilical artery Doppler measurement.

Results There was no significant changes of umbilical artery resistance index (RI) (0.69 ± 0.049 vs. 0.68 ± 0.041), umbilical artery PI (1.14 ± 0.118 vs. 1.11 ± 0.116), uterine artery RI (0.66 ± 0.12 vs. 0.66 ± 0.107), uterine artery PI (1.00 ± 0.26 vs. 1.016 ± 0.24), and MCA PI (1.27 ± 0.18 vs. 1.26 ± 0.23) measurements before and after 1 week of P administration, respectively.

Conclusion Administration of vaginal P has no significant effects on uterine artery, umbilical artery, and MCA Doppler indices.

Keywords

progesterone - preterm birth - umbilical artery Doppler - uterine artery Doppler - middle cerebral artery Doppler

Full Text

References

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