Acetazolamide-Induced Aseptic Meningitis in a Female Adolescent with Idiopathic Intracranial Hypertension: A Case Report

Abstract

Drug-induced aseptic meningitis (DIAM) has been documented for many years and is considered a diagnostic and patient management challenge. Associated medications include nonsteroidal anti-inflammatory drugs, antibiotics, and monoclonal antibodies, but no cases associated with acetazolamide have been reported. We briefly review a case of a 15-year-old female patient with history of idiopathic intracranial hypertension whose symptoms of aseptic meningitis associated with the use and increase of acetazolamide. DIAM should be considered a possibility in any patient with meningeal symptoms, pleocytosis, and negative cerebrospinal fluid culture. This is the first known case linking acetazolamide to DIAM.

Keywords

headache - idiopathic intracranial hypertension - acetazolamide - drug-induced aseptic meningitis

Authors' Contributions

R.G. reviewed the literature, drafted the initial manuscript, and reviewed and revised the manuscript. C.B. critically reviewed, edited, and revised the manuscript. V.P. was principally involved in the case, as well as critically reviewed, edited, and revised the manuscript. All authors approved the final manuscript as submitted and agreed to be accountable for all aspects of the work.

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